STTR Phase I: A Mobile Triage Application for Reducing the Risk of COPD Exacerbations

STTR 第一阶段：用于降低 COPD 恶化风险的移动分诊应用程序

• 批准号: 1820049
• 负责人: Sumanth Swaminathan
• 金额: $ 22.5万
• 依托单位: E-THERA, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1820049&HistoricalAwards=false
• 关键词: STTR; Phase; Mobile; Triage; Application

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is the reduction of significant disease flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD), increase in patient quality-of-life, and a reduction of expensive and unnecessary healthcare utilization. Current at-home care support for COPD patients is often completely missing or consists of action plans that fail to provide effective, individualized care. The alternative solution under development in this project is an easy-to use, personalized mobile application that catches disease degeneration early, tracks patient health history, and provides decision support to guide patients to the right medical care at the right time. COPD is one of the leading chronic conditions driving potentially avoidable hospital admissions. Pairing a mobile health management app with a smart triage system that provides instant healthcare guidance has the potential to dramatically reduce unnecessary COPD hospitalization and provide long-term maintenance treatment of COPD symptoms. Moreover, an easily accessible, highly accurate, convenient solution can empower patients to make better health decisions early. This STTR Phase I project proposes to demonstrate positive impact and adoption of a mobile triage application for COPD patients. To date, a set of triage algorithms has been built and validated on simulated patient cases. The algorithms exhibited performance that is comparable to or better than a panel of board-certified pulmonologists. The next vital step is to establish the technical feasibility of a packaged, stand-alone mobile application. This research will focus on developing a fully featured prototype that is optimized for adoption, retention, and efficacy. A mix of user feedback and rigorous usage analysis collected through human testing will provide necessary insights on barriers to use, missing functionality, and consumer value. Standardized markers of health safety, symptom escalations, and patient quality-of-life will be used as metrics of product performance. Moreover, all data and conclusions will be subjected to peer review through publication and public presentations. As an additional objective, the accuracy of the algorithmic triage recommendations will be tested on real patient cases to further validate their accuracy and effectiveness. The anticipated result of the phase I procedure is demonstration that the app is safe (objective 1), operationally sound and optimal (phase 2), and valuable to consumers (objective 3).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业技术转让（STTR）项目的更广泛的影响/商业潜力是减少慢性阻塞性肺疾病（COPD）患者的重大疾病发作，提高患者的生活质量，并减少昂贵和不必要的医疗保健使用。目前对COPD患者的家庭护理支持通常完全缺失或由无法提供有效的个性化护理的行动计划组成。该项目正在开发的替代解决方案是一种易于使用的个性化移动的应用程序，可早期发现疾病恶化，跟踪患者健康史，并提供决策支持，以指导患者在正确的时间接受正确的医疗护理。慢性阻塞性肺病是一种主要的慢性疾病，可能导致可避免的住院。将移动的健康管理应用程序与提供即时医疗保健指导的智能分诊系统配对，有可能大大减少不必要的COPD住院治疗，并为COPD症状提供长期维持治疗。此外，一个易于访问、高度准确、方便的解决方案可以使患者尽早做出更好的健康决策。该STTR I期项目旨在证明移动的分诊应用程序对COPD患者的积极影响和采用。迄今为止，已经在模拟患者病例上构建并验证了一套分类算法。这些算法表现出的性能与委员会认证的肺病学家小组相当或更好。下一个关键步骤是建立一个打包的、独立的移动的应用程序的技术可行性。这项研究将专注于开发一个功能齐全的原型，该原型针对采用，保留和功效进行了优化。通过人工测试收集的用户反馈和严格的使用分析将为使用障碍、缺失功能和消费者价值提供必要的见解。健康安全性、症状升级和患者生活质量的标准化标志物将用作产品性能的指标。此外，所有数据和结论都将通过出版物和公开介绍接受同行审查。作为一个额外的目标，算法分类建议的准确性将在真实的患者病例上进行测试，以进一步验证其准确性和有效性。第一阶段程序的预期结果是证明该应用程序是安全的（目标1），操作合理和最佳的（阶段2），并对消费者有价值（目标3）。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。