SBIR Phase I: Marangoni Processing for the Stabilization of Biologically Active Surfaces

SBIR 第一阶段：用于稳定生物活性表面的 Marangoni 处理

• 批准号: 1820032
• 负责人: Quinn Osgood
• 金额: $ 22.5万
• 依托单位: Otzi Bio LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1820032&HistoricalAwards=false
• 关键词: SBIR; Phase; Marangoni; Processing; Stabilization

This Small Business Innovation Research Phase I project proposes development and optimization of a surface tension mediated lyoprocessing technique for long-term storage of biologically active surfaces and other biological materials at ambient or above cryogenic temperatures. Stabilization of temperature sensitive biological materials at ambient temperatures can address significant bottlenecks that prevents economic distribution of pharmaceutically relevant biomolecules worldwide. In addition, the implementation of this technology has the potential to greatly improve global health, particularly in developing regions where many advanced treatments are unavailable as a result of their temperature sensitivity. Overall, this project aims at offering an alternative technology platform to stabilize temperature sensitive biological materials at non-cryogenic temperatures. The intellectual merit of this project lies primarily in the approach used to achieve stable desiccated storage. The project aims at translating a newly developed drystate biopreservation processing methodology into a commercially viable, mechanized, long-term biopreservation technique. The newly developed biopreservation technology provides a way to efficiently process biologically active surfaces containing bioactive components, assay reagents, cells and cellular components, and other biomolecules for long-term stability at non-cryogenic temperatures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究第一阶段项目提出了一种表面张力介导的冻干技术的开发和优化，用于在环境温度或高于低温温度下长期储存生物活性表面和其他生物材料。温度敏感生物材料在环境温度下的稳定化可以解决阻碍药物相关生物分子在世界范围内经济分布的重大瓶颈。此外，这项技术的实施有可能大大改善全球健康，特别是在发展中地区，由于其温度敏感性，许多先进的治疗方法无法获得。总的来说，该项目旨在提供一种替代技术平台，以在非低温下稳定温度敏感的生物材料。该项目的智力价值主要在于用于实现稳定干燥储存的方法。该项目旨在将新开发的干态生物保存处理方法转化为商业上可行的机械化长期生物保存技术。新开发的生物保存技术提供了一种有效处理生物活性表面的方法，该表面含有生物活性成分、检测试剂、细胞和细胞成分以及其他生物分子，可在非低温下长期稳定。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。