SBIR Phase I: Marangoni Processing for the Stabilization of Biologically Active Surfaces

这个小企业创新研究第一阶段项目提出了一种表面张力介导的冷冻处理技术的开发和优化，用于在室温或高于低温的条件下长期储存生物活性表面和其他生物材料。温度敏感生物材料在环境温度下的稳定可以解决阻碍全球范围内药学相关生物分子经济分布的重大瓶颈。此外，这项技术的实施有可能大大改善全球健康状况，特别是在发展中地区，由于这些地区对温度敏感，无法获得许多先进的治疗方法。总体而言，该项目旨在提供一种替代技术平台，在非低温下稳定温度敏感的生物材料。该项目的智力优势主要在于用于实现稳定的干燥存储的方法。该项目旨在将新开发的干态生物保存处理方法转化为商业上可行的、机械化的、长期的生物保存技术。新开发的生物保存技术提供了一种有效处理含有生物活性成分、分析试剂、细胞和细胞成分以及其他生物分子的生物活性表面的方法，以实现非低温下的长期稳定性。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This Small Business Innovation Research Phase I project proposes development and optimization of a surface tension mediated lyoprocessing technique for long-term storage of biologically active surfaces and other biological materials at ambient or above cryogenic temperatures. Stabilization of temperature sensitive biological materials at ambient temperatures can address significant bottlenecks that prevents economic distribution of pharmaceutically relevant biomolecules worldwide. In addition, the implementation of this technology has the potential to greatly improve global health, particularly in developing regions where many advanced treatments are unavailable as a result of their temperature sensitivity. Overall, this project aims at offering an alternative technology platform to stabilize temperature sensitive biological materials at non-cryogenic temperatures. The intellectual merit of this project lies primarily in the approach used to achieve stable desiccated storage. The project aims at translating a newly developed drystate biopreservation processing methodology into a commercially viable, mechanized, long-term biopreservation technique. The newly developed biopreservation technology provides a way to efficiently process biologically active surfaces containing bioactive components, assay reagents, cells and cellular components, and other biomolecules for long-term stability at non-cryogenic temperatures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.