Functional impact of clock genes on circadian timing of metabolism: a metabolomics approach (A04)

该项目将采用代谢组学的方法，研究中心生物钟和脂肪生物钟对新陈代谢时间的功能影响。在已确定的振荡代谢物的基础上，我们的目标是澄清这些代谢物是否以昼夜节律的方式进行调节，并研究大脑和脂肪体中的分子时钟对代谢振荡的影响。在中央生物钟和肥胖生物钟失去同步后，将分析受干扰的生物钟的新陈代谢后果。生物钟对调节摄食行为和新陈代谢到生理最佳状态的功能意义将在另一个工作包中进行测试。在CRC中，A4还将作为中心代谢物分析和代谢组学核心单位发挥作用。

The project will study the functional impact of the central and fat body clock on the timing of metabolism by taking a metabolomics approach. Building on the already identified oscillating metabolites, we aim to clarify whether these metabolites are regulated in a circadian fashion and study the impact of the molecular clock in the brain and the fat body on metabolic oscillations. After desynchronization of the central and fat body clocks, the metabolic consequences of the disturbed clockwork will be analyzed. The functional significance of circadian clocks for adjusting feeding behavior and metabolism to the physiological optimum will be tested in another work package. Within the CRC, A4 will also function as a central metabolite analysis and metabolomics core unit.