Functional impact of clock genes on circadian timing of metabolism: a metabolomics approach (A04)

时钟基因对代谢昼夜节律的功能影响：代谢组学方法 (A04)

• 批准号: 234395780
• 金额: --
• 依托单位: Julius-von-Sachs-Institut für Biowissenschaften
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/234395780?language=en
• 关键词: Functional; impact; clock; genes; circadian

The project will study the functional impact of the central and fat body clock on the timing of metabolism by taking a metabolomics approach. Building on the already identified oscillating metabolites, we aim to clarify whether these metabolites are regulated in a circadian fashion and study the impact of the molecular clock in the brain and the fat body on metabolic oscillations. After desynchronization of the central and fat body clocks, the metabolic consequences of the disturbed clockwork will be analyzed. The functional significance of circadian clocks for adjusting feeding behavior and metabolism to the physiological optimum will be tested in another work package. Within the CRC, A4 will also function as a central metabolite analysis and metabolomics core unit.

该项目将通过代谢组学方法研究中枢和脂肪生物钟对代谢时间的功能影响。在已经确定的振荡代谢物的基础上，我们的目标是澄清这些代谢物是否以昼夜节律的方式进行调节，并研究大脑和脂肪体中的分子钟对代谢振荡的影响。在对中枢生物钟和脂肪生物钟进行去周期化之后，我们将分析生物钟紊乱所导致的代谢后果。将在另一个工作包中测试生物钟在调节摄食行为和代谢以达到生理最佳状态方面的功能意义。在CRC内，A4还将作为中心代谢物分析和代谢组学核心单元。