Cooperative and distinct functions of the protein kinases CK2 and RSK in regulation of the circadian clock and synaptic plasticity of Drosophila (A06)

这个项目的主要目标是将果蝇分子昼夜节律振荡器与选定的生理输出联系起来。结合分子、生化、遗传学和行为学的方法，我们想要确定蛋白激酶RSK是如何在分子水平上整合到时钟功能中的，是否需要RSK来将昼夜信息转化为适应性突触过程或进行时间依赖的学习，以及时钟神经元如何与大脑的神经前体细胞相互作用来影响它们的新陈代谢和增殖，这可能会对神经元的组成和行为产生影响。

The main objective of this project is to link the Drosophila molecular circadian oscillator with selected physiological outputs. Using a combination of molecular, biochemical, genetic and behavioral approaches we want to determine how protein kinase RSK is integrated into clock function at the molecular level, whether RSK is required to translate circadian information to adaptive synaptic processes or for time-dependent learning and how clock neurons interact with neural progenitor cells of the brain to influence their metabolism and proliferation, which might have an impact on neuronal composition and behavior.