Doctoral Dissertation Research: Maternal early life adversity, maternal care, and offspring survival

博士论文研究：母亲早年逆境、母亲护理和后代生存

• 批准号: 1826215
• 负责人: Susan Alberts
• 金额: $ 2.88万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826215&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Maternal; early

Adverse environmental conditions during growth and development can affect physiological function and well-being later in life. This dissertation project will investigate, in a primate model system, whether early-life adversity in primate mothers additionally influences traits in their offspring. Using longitudinal and newly collected data for a natural population of long-lived primates allows researchers to investigate intergenerational effects that may inform evolutionary theory and human health research without having to obtain multi-generation life history data from humans. The project will support international research collaborations, public and K-12 science outreach, and scientific training and mentoring for students from groups underrepresented in STEM fields. The Amboseli baboons have been under near-daily observation since 1971, resulting in extensive longitudinal demographic, environmental, and behavioral data. The investigators will use these existing data in conjunction with newly collected data on maternal care to test the hypothesis that mothers who experienced adversity during their developmental period provide relatively low quality maternal care to their offspring, leading to deficits in offspring survival. The research will therefore advance knowledge about proximate mechanisms of intergenerational transmission of stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生长和发育期间的不利环境条件会影响以后的生理功能和健康。本论文项目将调查，在灵长类动物模型系统中，是否在灵长类动物母亲的早期生活逆境另外影响其后代的性状。使用纵向和新收集的长寿灵长类动物自然种群的数据，使研究人员能够调查代际效应，这可能会为进化理论和人类健康研究提供信息，而无需从人类获得多代生活史数据。该项目将支持国际研究合作，公共和K-12科学推广，以及科学培训和指导来自STEM领域代表性不足的群体的学生。自1971年以来，安博塞利狒狒几乎每天都受到观察，从而获得了广泛的纵向人口统计，环境和行为数据。研究人员将使用这些现有数据与新收集的孕产妇护理数据相结合，以检验以下假设：在发育期间经历逆境的母亲为后代提供相对低质量的孕产妇护理，导致后代存活率下降。该研究将因此推进有关压力代际传递的近似机制的知识。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

Maternal death and offspring fitness in multiple wild primates

多种野生灵长类动物的孕产妇死亡和后代健康

• DOI: 10.1073/pnas.2015317118
• 发表时间: 2020
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Zipple, Matthew N.;Altmann, Jeanne;Campos, Fernando A.;Cords, Marina;Fedigan, Linda M.;Lawler, Richard R.;Lonsdorf, Elizabeth V.;Perry, Susan;Pusey, Anne E.;Stoinski, Tara S.
• 通讯作者: Stoinski, Tara S.

Intergenerational effects of early adversity on survival in wild baboons

早期逆境对野生狒狒生存的代际影响

• DOI: 10.7554/elife.47433
• 发表时间: 2019
• 期刊: eLife
• 影响因子: 7.7
• 作者: Zipple, Matthew N;Archie, Elizabeth A;Tung, Jenny;Altmann, Jeanne;Alberts, Susan C
• 通讯作者: Alberts, Susan C