Doctoral Dissertation Research: Maternal early life adversity, maternal care, and offspring survival

博士论文研究：母亲早年逆境、母亲护理和后代生存

• 批准号: 1826215
• 负责人: Susan Alberts
• 金额: $ 2.88万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826215&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Maternal; early

Adverse environmental conditions during growth and development can affect physiological function and well-being later in life. This dissertation project will investigate, in a primate model system, whether early-life adversity in primate mothers additionally influences traits in their offspring. Using longitudinal and newly collected data for a natural population of long-lived primates allows researchers to investigate intergenerational effects that may inform evolutionary theory and human health research without having to obtain multi-generation life history data from humans. The project will support international research collaborations, public and K-12 science outreach, and scientific training and mentoring for students from groups underrepresented in STEM fields. The Amboseli baboons have been under near-daily observation since 1971, resulting in extensive longitudinal demographic, environmental, and behavioral data. The investigators will use these existing data in conjunction with newly collected data on maternal care to test the hypothesis that mothers who experienced adversity during their developmental period provide relatively low quality maternal care to their offspring, leading to deficits in offspring survival. The research will therefore advance knowledge about proximate mechanisms of intergenerational transmission of stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生长和发育过程中的不利环境条件会影响生理功能和以后的生活。该论文项目将在灵长类动物模型系统中调查灵长类动物母亲的早期逆境是否会影响其后代的特征。使用纵向和新收集的数据为长期寿命灵长类动物的自然群体进行数据，可以研究代际效应，这些效应可能为进化论和人类健康研究提供依据，而无需从人类那里获得多代人寿史数据。该项目将支持国际研究合作，公共和K-12科学宣传，以及来自STEM领域中代表性不足的团体的学生的科学培训和指导。自1971年以来，Amboseli Baboons一直在几乎每天的观察中，导致广泛的纵向人口，环境和行为数据。研究人员将与新收集的有关孕产妇护理的数据结合使用这些现有数据，以测试以下假设：在发育时期经历过逆境的母亲为后代提供了相对较低的质量孕产妇护理，从而导致后代生存的不足。因此，这项研究将提高有关压力际传播的近端机制的知识。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响评估标准来评估值得支持的。

项目成果

Maternal death and offspring fitness in multiple wild primates

多种野生灵长类动物的孕产妇死亡和后代健康

• DOI: 10.1073/pnas.2015317118
• 发表时间: 2020
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Zipple, Matthew N.;Altmann, Jeanne;Campos, Fernando A.;Cords, Marina;Fedigan, Linda M.;Lawler, Richard R.;Lonsdorf, Elizabeth V.;Perry, Susan;Pusey, Anne E.;Stoinski, Tara S.
• 通讯作者: Stoinski, Tara S.

Intergenerational effects of early adversity on survival in wild baboons

早期逆境对野生狒狒生存的代际影响

• DOI: 10.7554/elife.47433
• 发表时间: 2019
• 期刊: eLife
• 影响因子: 7.7
• 作者: Zipple, Matthew N;Archie, Elizabeth A;Tung, Jenny;Altmann, Jeanne;Alberts, Susan C
• 通讯作者: Alberts, Susan C