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RII Track-2 FEC: Genomics Underlying Toxin Tolerance (GUTT): Identifying Molecular Innovations that Predict Phenotypes of Toxin Tolerance in Wild Vertebrate Herbivores

RII Track-2 FEC：毒素耐受性的基因组学 (GUTT)：识别预测野生脊椎动物草食动物毒素耐受性表型的分子创新

基本信息

批准号：
1826801
负责人：
Jennifer Forbey
金额：
$ 600万
依托单位：
Boise State University
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826801&HistoricalAwards=false
关键词：
RII Track FEC Genomics Underlying

项目摘要

Non-Technical DescriptionPlants and the animals that eat them are in a constant battle for survival that results in evolutionary change. Plants evolve to produce new toxic chemicals while herbivores, and their associated microbial communities, change such that they become more tolerant to plant toxins. The understanding of plant toxins and herbivore tolerance is important for conservation biologists that manage native herbivores and plants, for the ranching and agricultural community that rely on plants to feed livestock and chemicals to defend crops from pests, and the medical community that relies on plant-derived chemicals to manage human health. A better understanding of these important plant-herbivore systems will require the expertise of many scientists with different specializations that must cooperate across state boundaries. This project will leverage, build, and integrate research and education strengths across Idaho, Nevada, and Wyoming to identify the Genomes Underlying Toxin Tolerance (GUTT) in vertebrate herbivores. The GUTT team will integrate a range of expertise to identify how variation in toxin tolerance influences populations of wild mammalian and avian herbivores. The team will work with high school teachers and use Course-based Undergraduate Research Experiences in introductory biology, chemistry, and math courses to train, inspire, recruit, and retain a diverse workforce capable of applying genetic understanding of toxin tolerance in animals and microbes to conservation, agriculture and human health. The project will also connect GUTT participants with local agency and industry partners to diversify career and funding opportunities for faculty and students. The research and educational activities will increase the capacity for Idaho, Nevada, and Wyoming faculty, students, and community partners to more effectively manage toxic plants and the animals and microbes that interact with these plants.Technical DescriptionThis project identifies the Genomes Underlying Toxin Tolerance (GUTT) by establishing the links between molecular and physiological mechanisms of toxin tolerance that predict demographic consequences in vertebrate herbivores. The researchers use metabolomics, transcriptomics, metagenomics, and molecular modeling to identify molecular interactions between herbivore and gut microbial genomes and toxic chemicals ingested by herbivores. The team will use in vivo and in vitro experiments to quantify physiological mechanisms of toxin tolerance and physiological consequences of toxin exposure. Participants will also work on manipulating molecular and physiological mechanisms of toxin tolerance to develop, validate, and iteratively refine models that predict how toxin exposure influences herbivore demography. The research will result in: 1) An unprecedented, detailed view of concerted herbivore and microbial response to, and modification of, toxins in the herbivore gut that influence demographic rates of native vertebrate herbivores; 2) Discovery and archiving of chemical, genetic, and microbial diversity from unique interactions created in the guts of mammalian and avian herbivores consuming diverse plant chemicals; and 3) Workforce development programs that create and sustain a culture of inclusion for marginalized groups across all career stages who can innovate and lead new frontiers in integrated research and educational practices. High school outreach programs and interactions with predominantly undergraduate institutions will be used to inspire the next generation of scientists. Rentention of these students will be ensured through Course-based Undergraduate Research Experiences throughout the undergraduate curriculum where students use genetic and chemical data to discover novel mechanisms and consequences of toxin tolerance. Overall, the Idaho, Nevada, and Wyoming EPSCoR RII Track-2 GUTT team will foster novel collaborations and contribute to society by predicting and managing how wild, agricultural, and human systems respond molecularly, physiologically, and demographically to chemicals in plants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术描述植物和以它们为食的动物为了生存而不断地进行斗争，从而导致了进化的变化。植物进化产生新的有毒化学物质，而食草动物及其相关的微生物群落发生变化，使它们对植物毒素变得更加耐受。了解植物毒素和草食动物耐受性对于管理本地草食动物和植物的保护生物学家、依靠植物喂养牲畜和化学品来保护作物免受害虫侵害的牧场和农业社区以及依靠植物源化学品来管理人类健康的医学界都很重要。为了更好地了解这些重要的植物-草食动物系统，需要许多具有不同专业知识的科学家的专业知识，这些科学家必须跨越国界进行合作。该项目将利用、建立和整合爱达荷州、内华达州和怀俄明州的研究和教育优势，以确定脊椎动物草食动物的毒素耐受性基因组 (GUTT)。 GUTT 团队将整合一系列专业知识，以确定毒素耐受性的变化如何影响野生哺乳动物和鸟类食草动物的种群。该团队将与高中教师合作，利用生物、化学和数学入门课程中基于课程的本科生研究经验来培训、激励、招募和留住一支多元化的劳动力队伍，他们能够将动物和微生物毒素耐受性的遗传理解应用于保护、农业和人类健康。该项目还将 GUTT 参与者与当地机构和行业合作伙伴联系起来，为教师和学生提供多样化的职业和资助机会。研究和教育活动将提高爱达荷州、内华达州和怀俄明州教师、学生和社区合作伙伴的能力，以更有效地管理有毒植物以及与这些植物相互作用的动物和微生物。技术描述该项目通过建立毒素耐受性的分子和生理机制之间的联系来识别潜在的毒素耐受性（GUTT），从而预测人口统计结果脊椎动物食草动物。研究人员利用代谢组学、转录组学、宏基因组学和分子模型来识别食草动物和肠道微生物基因组以及食草动物摄入的有毒化学物质之间的分子相互作用。该团队将利用体内和体外实验来量化毒素耐受的生理机制和毒素暴露的生理后果。参与者还将致力于操纵毒素耐受性的分子和生理机制，以开发、验证和迭代完善预测毒素暴露如何影响草食动物人口统计的模型。该研究将导致：1）前所未有地详细了解食草动物和微生物对食草动物肠道毒素的协同反应和修改，这些毒素影响本地脊椎动物食草动物的人口比例； 2）通过消耗不同植物化学品的哺乳动物和鸟类食草动物肠道中产生的独特相互作用来发现和归档化学、遗传和微生物多样性； 3) 劳动力发展计划，为各个职业阶段的边缘化群体创造并维持一种包容文化，这些群体能够在综合研究和教育实践方面创新并引领新领域。高中外展计划以及与本科院校为主的互动将用于激励下一代科学家。这些学生的保留将通过整个本科课程中基于课程的本科生研究经验来确保，学生使用遗传和化学数据来发现毒素耐受性的新机制和后果。总体而言，爱达荷州、内华达州和怀俄明州的 EPSCoR RII Track-2 GUTT 团队将通过预测和管理野生、农业和人类系统如何对植物中的化学物质做出分子、生理和人口反应，促进新颖的合作并为社会做出贡献。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查进行评估，被认为值得支持标准。

项目成果

期刊论文数量（51）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Capturing conservation in the post-genomics era: a book review of “Conservation and the Genomics of Populations.”

捕捉后基因组时代的保护：《保护与种群基因组学》书评。

DOI：
10.1007/s10592-022-01481-3
发表时间：
2023
期刊：
Conservation Genetics
影响因子：
2.2
作者：
Galla, Stephanie J.;Mittan-Moreau, Cinnamon S.;Barbosa, Soraia
通讯作者：
Barbosa, Soraia

Editorial: Arthropod Interactions and Responses to Disturbance in a Changing World

社论：不断变化的世界中节肢动物的相互作用和对干扰的反应

DOI：
10.3389/fevo.2020.00093
发表时间：
2020
期刊：
Frontiers in Ecology and Evolution
影响因子：
3
作者：
Murphy, Shannon M.;Richards, Lora A.;Wimp, Gina M.
通讯作者：
Wimp, Gina M.

Unifying community detection across scales from genomes to landscapes

DOI：
10.1111/oik.08393
发表时间：
2021-04
期刊：
Oikos
影响因子：
3.4
作者：
Stephanie F. Hudon;A. Zaiats;Anna V. Roser;A. Roopsind;Cristina Barber;B. Robb;Britt Pendleton;Meghan J. Camp;Patrick E. Clark;Merry M. Davidson;Jonas Frankel‐Bricker;Marcella R. Fremgen-Tarantino;J. Forbey;Eric J. Hayden;Lora A. Richards;Olivia K. Rodríguez;T. T. Caughlin-T.
通讯作者：
Stephanie F. Hudon;A. Zaiats;Anna V. Roser;A. Roopsind;Cristina Barber;B. Robb;Britt Pendleton;Meghan J. Camp;Patrick E. Clark;Merry M. Davidson;Jonas Frankel‐Bricker;Marcella R. Fremgen-Tarantino;J. Forbey;Eric J. Hayden;Lora A. Richards;Olivia K. Rodríguez;T. T. Caughlin-T.

The interplay between diet, gut microbes, and host epigenetics in health and disease.