Role of hippocampal BDNF signaling in contextual fear learning, fear generalization and context discrimination (A10)

海马 BDNF 信号在情境恐惧学习、恐惧泛化和情境辨别中的作用 (A10)

• 批准号: 234585859
• 金额: --
• 依托单位: Institut für Klinische Neurobiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/234585859?language=en
• 关键词: Role; hippocampal; BDNF; signaling; contextual

Behavioral analyses of a newly generated mouse model with selective depletion of BDNF from hippocampal granule cells showed altered processing of learned fear and increased hippocampal activity that correlated with delayed extinction. This and other BDNF deficient mouse models will be studied to characterize altered signal transduction, synaptic plasticity in local GABAergic interneurons in the MF-CA3 region, and to correlate changes in activity with behavioral alterations in context of discrimination and fear generalization.

行为分析的一个新产生的小鼠模型与选择性耗尽的BDNF从海马颗粒细胞显示改变了学习的恐惧和增加海马活动，与延迟灭绝。将研究这种和其他BDNF缺陷小鼠模型，以表征MF-CA 3区域中局部GABA能中间神经元中改变的信号转导、突触可塑性，并将活动变化与歧视和恐惧泛化背景下的行为改变相关联。