MRI: Acquisition of a microfluidic-based 3D printer for additive manufacturing of biomaterials for fabrication of tissue-on-a-chip models.

MRI：购买基于微流体的 3D 打印机，用于增材制造生物材料，用于制造芯片组织模型。

• 批准号: 1828268
• 负责人: Binata Joddar
• 金额: $ 25.58万
• 依托单位: University of Texas at El Paso
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828268&HistoricalAwards=false
• 关键词: MRI; Acquisition; microfluidic; based; 3D

This award from the Major Research Instrumentation program supports the University of Texas at El Paso (UTEP) with the acquisition of a Lab-on-a-Printer (LOP) with RX1 Bioprinting Platform. The instrument will enable accelerated fundamental 3D-bioprinting research at UTEP. The LOP technology is uniquely capable of combining multiple cell types and biomaterial inputs on a single printhead cartridge, enabling the precise deposition of different cells and materials in 3D to recreate and mimic the complex structure of real tissue. The RX1 Bioprinting Platform uses the LOP technology to rapidly and precisely construct functional 3D living tissue, with an advanced material processing capability providing accurate control over patterning of the biological building blocks, rapidly. At UTEP, the RX1 Bioprinting Platform will be used in several high impact projects including, engineering tissues with blood vessels, the human heart wall, tissues for nerve regeneration and developmental biology, and the application of novel 2D/advanced materials for in-vitro studies. Concurrently, the RX1 Bioprinting Platform will provide sustained and cross-disciplinary studies while contributing to and advancing STEM education and training by providing students access to cutting-edge teaching, research technologies and opportunities. The main objective of the researchers is to employ the Lab-on-a-Printer (LOP) to utilize hydrogels (synthetic and naturally derived) as scaffolds for bioprinting aimed at tissue-on-a-chip studies. In addition, non-hydrogel type materials such as polymer blends (including Polyurethane, PCL-PLLA), shape memory polymers and nanocomposites with nanowire inclusions will also be targeted. The 3D-printed constructs will include biological neural network development, dose optimization/ minimization of small molecule based therapeutics and enhanced dielectric energy storage and energy harvesting for energy related applications. The LOP technology can easily enable printing of soft structures (such as tissues) which provides needed exploration of biomaterial with advantageous properties than currently possible. The instrument will support multidisciplinary, team-based opportunities involving Engineering faculty at UTEP and faculty from other scientific disciplines and help establish new critical regional collaborations within the state of Texas and neighboring New Mexico. The technology and hands-on use of this printer will be incorporated into existing or new courses with laboratory component, exposing nearly 100 students annually to this technology. It will strengthen outreach to the community, local middle- and high-school students. It will lead to new industry-academic collaborations benefiting both the scientific community at UTEP and industry, nationwide.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项来自主要研究仪器计划的奖项支持德克萨斯大学埃尔帕索分校 (UTEP) 购买带有 RX1 生物打印平台的打印机实验室 (LOP)。该仪器将加速 UTEP 的基础 3D 生物打印研究。 LOP 技术具有独特的能力，能够在单个打印头墨盒上组合多种细胞类型和生物材料输入，从而能够在 3D 中精确沉积不同的细胞和材料，以重建和模拟真实组织的复杂结构。 RX1 生物打印平台使用 LOP 技术快速、精确地构建功能性 3D 活体组织，并具有先进的材料处理能力，可快速准确地控制生物构件的图案。 在 UTEP，RX1 生物打印平台将用于几个高影响力的项目，包括工程组织血管、人体心脏壁、神经再生和发育生物学组织，以及新型 2D/先进材料在体外研究中的应用。同时，RX1 生物打印平台将提供持续的跨学科研究，同时通过为学生提供尖端的教学、研究技术和机会，促进和推进 STEM 教育和培训。研究人员的主要目标是利用打印机实验室（LOP）利用水凝胶（合成的和天然衍生的）作为生物打印支架，旨在进行芯片组织研究。此外，非水凝胶型材料，如聚合物共混物（包括聚氨酯、PCL-PLLA）、形状记忆聚合物和含有纳米线的纳米复合材料也将成为目标。 3D 打印结构将包括生物神经网络开发、基于小分子的疗法的剂量优化/最小化以及用于能源相关应用的增强介电能量存储和能量收集。 LOP 技术可以轻松实现软结构（例如组织）的打印，这为生物材料提供了所需的探索，其特性比目前可能的更有利。该工具将支持涉及 UTEP 工程学院和其他科学学科教师的多学科、基于团队的机会，并帮助在德克萨斯州和邻近的新墨西哥州建立新的重要区域合作。该打印机的技术和实践使用将被纳入现有或带有实验室部分的新课程中，每年让近 100 名学生接触到该技术。它将加强对社区、当地中学生和高中生的宣传。它将带来新的产学合作，使 UTEP 的科学界和全国工业界受益。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Hydrogel scaffolds with elasticity-mimicking embryonic substrates promote cardiac cellular network formation

• DOI: 10.1007/s40204-020-00137-0
• 发表时间: 2020-09-25
• 期刊: PROGRESS IN BIOMATERIALS
• 影响因子: 4.9
• 作者: Alonzo, Matthew;Kumar, Shweta Anil;Joddar, Binata
• 通讯作者: Joddar, Binata

A Comparative Study in the Printability of a Bioink and 3D Models Across Two Bioprinting Platforms.

两个生物打印平台的生物墨水和 3D 模型的可打印性比较研究。

• DOI: 10.1016/j.matlet.2020.127382
• 发表时间: 2020
• 期刊: Materials letters
• 影响因子: 3
• 作者: Alonzo,Matthew;Dominguez,Erick;Alvarez-Primo,Fabian;Quinonez,Amado;Munoz,Erik;Puebla,Jazmin;Barron,Antonio;Aguirre,Luis;Vargas,Ana;Ramirez,JeanM;Joddar,Binata
• 通讯作者: Joddar,Binata

3D Bioprinted Spheroidal Droplets for Engineering the Heterocellular Coupling between Cardiomyocytes and Cardiac Fibroblasts

• DOI: 10.34133/2021/9864212
• 发表时间: 2021-12-28
• 期刊: CYBORG AND BIONIC SYSTEMS
• 作者: El Khoury, Raven;Nagiah, Naveen;Joddar, Binata
• 通讯作者: Joddar, Binata

Fabrication of Surfactant-Dispersed HiPco Single-Walled Carbon Nanotube-Based Alginate Hydrogel Composites as Cellular Products

• DOI: 10.3390/ijms20194802
• 发表时间: 2019-10-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Alvarez-Primo, Fabian;Kumar, Shweta Anil;Joddar, Binata
• 通讯作者: Joddar, Binata