Excellence in Research: Engineering Two-dimensional Transition Metal Dichalcogenide Nanomaterials for Sweat Sensing

卓越研究：工程二维过渡金属二硫族化物纳米材料用于汗液传感

• 批准号: 1831133
• 负责人: Fei Yan
• 金额: $ 50万
• 依托单位: North Carolina Central University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831133&HistoricalAwards=false
• 关键词: Excellence; Research; Engineering; Two; dimensional

This project seeks to boost participation and academic success of underrepresented minority students in the Department of Chemistry and Biochemistry at North Carolina Central University, a historically black university. The research builds on our extensive research experience in sensor development and nanotechnology, and will benefit from the close collaboration with scientists in the Department of Materials Science and Engineering and Department of Chemical and Biomolecular Engineering at North Carolina State University. Specifically, the grant will provide support for eight undergraduate students and four graduate students for their independent and/or thesis research. The students will be involved in the development of flexible and cost-effective platforms for sweat sensing, which will considerably improve our ability of tracking a person's physiological state in a real-time fashion, and will thus provide a new opportunity for medical diagnostics and therapy. The students will use the knowledge and experience gained in the research to prepare for future careers in Science, Technology, Engineering and Mathematics disciplines, industry, and/or higher education. Moreover, the strategies developed in this study are expected to provide new insights into a wider range of applications in environmental monitoring, forensic investigation, and medical diagnostics.The goal of this project is to develop a novel wearable technology for real-time monitoring of the various trace constituents in sweat, these include water, electrolytes (e.g., chloride, sodium, potassium, magnesium and ammonium etc.), and metabolites (e.g. lactate and glucose). Real-time sweat sensing presents an intriguing and cost-effective way to monitor the well-being of human body, which would be very useful for early stage medical diagnose and healthcare. However, the current sensing technique usually fall short of providing satisfactory portability, sensitivity, and selectivity. Two-dimensional (2D) ultrathin layered transition metal dichalcogenide (TMD) materials emerged as a promising substrate for sweat sensing. The proposed research will focus on three integrated objectives: 1) Understanding the fundamentals of sweat sensing with 2D TMD materials, 2) Developing capabilities to synthesize pristine 2D TMD nan sheets and noble metal nanoparticle-TMD heterostructures with desirable chemo-physical properties, and 3) Developing prototype 2D TMD materials-based sensors showing capabilities of sensing the constituents of sweat with high sensitivity and selectivity. Along with the proposed work on research and development of 2D materials-based sweat sensing devices, outreach and education activities will be integrated to broaden participation in scientific research, to train next-generation work forces, and to broadly disseminate the results to the community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在促进北卡罗来纳州中央大学化学和生物化学系中代表性不足的少数民族学生的参与和学术成就，这是一所历史悠久的黑人大学。这项研究建立在我们在传感器开发和纳米技术方面的丰富研究经验的基础上，并将受益于与北卡罗来纳州州立大学材料科学与工程系和化学与生物分子工程系科学家的密切合作。具体而言，该补助金将为8名本科生和4名研究生提供独立和/或论文研究的支持。学生将参与开发灵活且具有成本效益的汗液传感平台，这将大大提高我们实时跟踪人的生理状态的能力，从而为医疗诊断和治疗提供新的机会。学生将利用在研究中获得的知识和经验，为科学，技术，工程和数学学科，工业和/或高等教育的未来职业做准备。此外，本研究中开发的策略有望为环境监测、法医调查和医疗诊断等更广泛的应用提供新的见解。本项目的目标是开发一种新型的可穿戴技术，用于实时监测汗液中的各种微量成分，包括水、电解质（例如，氯化物、钠、钾、镁和铵等），和代谢物（例如乳酸盐和葡萄糖）。实时汗液传感提供了一种有趣且具有成本效益的方法来监测人体的健康状况，这对于早期医疗诊断和医疗保健非常有用。然而，电流感测技术通常达不到提供令人满意的便携性、灵敏度和选择性。二维（2D）层状过渡金属二硫属化物（TMD）材料成为一种有前途的汗液传感基底。拟议的研究将集中在三个综合目标：1）了解与二维TMD材料的汗液传感的基本原理，2）开发能力，以合成原始的二维TMD纳米片和贵金属纳米颗粒-TMD异质结构具有理想的化学物理性能，和3）开发原型二维TMD材料为基础的传感器显示具有高灵敏度和选择性的传感汗液成分的能力。沿着关于研究和开发基于2D材料的汗液传感设备的拟议工作，将整合推广和教育活动，以扩大对科学研究的参与，培养下一代劳动力，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响进行评估，被认为值得支持审查标准。

项目成果

Optimizing the synergistic effect of CuWO 4 /CuS hybrid composites for photocatalytic inactivation of pathogenic bacteria

优化CuWO 4 /CuS杂化复合材料光催化灭活病原菌的协同效应

• DOI: 10.1039/d2en00361a
• 发表时间: 2022
• 期刊: Environmental Science: Nano
• 作者: Dong, Xiuli;Katzbaer, Rowan R.;Chitara, Basant;Han, Li;Yang, Liju;Schaak, Raymond E.;Yan, Fei
• 通讯作者: Yan, Fei

Ultrastrong Raman Enhancement on Gold Nanoparticle-Decorated Transition Metal Dichalcogenides Nanosheets for Molecule Detection

用于分子检测的金纳米粒子修饰的过渡金属二硫化物纳米片的超强拉曼增强

• DOI: 10.13526/j.issn.1006-6144.2019.06.018
• 发表时间: 2019
• 期刊: Fenxi kexue xuebao
• 作者: Orlando, J;Kahn, E;Wong, CY;Limbu, T;Chitara, B;Elias, A.L.;Terrones, M.;Yan, F.
• 通讯作者: Yan, F.

Near-Infrared Photodetectors Based on 2D Bi2S3

• DOI: 10.1016/j.cplett.2022.139876
• 发表时间: 2022-07
• 期刊: Chemical Physics Letters
• 影响因子: 2.8
• 作者: Basant Chitara;Fei Yan

Rose bengal-integrated electrospun polyacrylonitrile nanofibers for photodynamic inactivation of bacteria

玫瑰红集成电纺聚丙烯腈纳米纤维用于光动力灭活细菌

• DOI: 10.1039/d2va00166g
• 发表时间: 2022
• 期刊: Environmental Science: Advances
• 作者: Dong, Xiuli;Mitchell, Dionne G.;Garcia Cervantes, Martha Y.;Chitara, Basant;Yang, Liju;Yan, Fei
• 通讯作者: Yan, Fei

N-halamine-decorated electrospun polyacrylonitrile nanofibrous membranes: characterization and antimicrobial properties

• DOI: 10.1016/j.reactfunctpolym.2021.105058
• 发表时间: 2021-10-01
• 期刊: REACTIVE & FUNCTIONAL POLYMERS
• 影响因子: 5.1
• 作者: Cervantes, Martha Y. Garcia;Han, Li;Yan, Fei
• 通讯作者: Yan, Fei