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Excellence in Research: Unlocking the Synthetic Power of Regioselective and Stereoselective Carbon Carbon Bond Formations for Multicomponent Reactions in Heterocycle Synthesis

卓越研究：释放杂环合成中多组分反应的区域选择性和立体选择性碳碳键形成的合成能力

基本信息

批准号：
1831339
负责人：
Fenghai Guo
金额：
$ 42万
依托单位：
Winston-Salem State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831339&HistoricalAwards=false
关键词：
Excellence Research Unlocking Synthetic Power

项目摘要

The HBCU Excellence in Research program supports the project by Professor Fenghai Guo. Professor Fenghai Guo is a faculty member in the Department of Chemistry at Winston Salem State University. In the proposed project, Professor Guo and his group are developing new reactions that allow for efficient construction of new carbon-carbon bonds. The bonds are found in the nitrogen, sulfur, and oxygen based ring skeletons that form the core of many medicinally active molecules. The chemistry takes advantage of metal-based reagents that lower the energetic barrier for reactions that assemble larger molecules from multiple smaller, more readily available building blocks in a single step. In addition to these scientific goals, the research project provides research experiences for STEM undergraduates who are from underrepresented groups. To that end, Professor Guo's group is ideally located at Winston Salem State University. In addition to working with the undergraduate students at Winston Salem State University, the PI and his group are involved in outreach activities that provide high school interns with opportunities to pursue research in the area of synthetic chemistry. Carbon carbon bond formation is very valuable in forming the carbon skeletons of complex heterocycles. In this project, Professor Guo is developing multicomponent reactions that consist of tandem 1,4- and 1,6-conjugate addition-acylation sequences and tandem 1,4-, 1,6-conjugate additions coupled with oxidative coupling reactions. The reactions lead to the generation of multiple C-C bonds and stereocenters. The research is generating new knowledge in terms of the selectivity available to metal catalyzed conjugate addition reactions and the generation of new heterocyclics. The utility of the method is being illustrated by its application to the synthesis of bioactive, complex heterocyclic ring systems. The educational Broader Impact of the work centers on the opportunities it is providing for students from underrepresented groups to gain research experience in synthetic chemistry. Winston Salem State University serves as a gateway to the sciences for many African American and underrepresented minority students. In this way, the Guo group is ideally positioned to have a significant educational Broader Impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

HBCU卓越研究项目支持郭凤海教授的项目。郭凤海教授是温斯顿塞勒姆州立大学化学系的教员。在提议的项目中，郭教授和他的团队正在开发新的反应，可以有效地构建新的碳-碳键。这些化学键存在于氮、硫和氧基环骨架中，它们构成了许多具有药用活性的分子的核心。这种化学方法利用了金属基试剂的优势，降低了反应的能量屏障，从而在一步中将多个更小、更容易获得的构建块组装成更大的分子。除了这些科学目标之外，该研究项目还为来自代表性不足群体的STEM本科生提供了研究经验。为此，郭教授的团队位于温斯顿塞勒姆州立大学。除了与温斯顿塞勒姆州立大学的本科生合作外，PI和他的团队还参与了一些外展活动，为高中实习生提供在合成化学领域进行研究的机会。碳-碳键的形成对杂环碳骨架的形成具有重要意义。在这个项目中，郭教授正在开发由串联1,4-和1,6-共轭加成-酰化序列和串联1,4-,1,6-共轭加成与氧化偶联反应组成的多组分反应。这些反应会生成多个碳-碳键和立体中心。该研究在金属催化共轭加成反应的选择性和新杂环的生成方面产生了新的知识。该方法在合成具有生物活性的复杂杂环体系中的应用证明了其实用性。这项工作在教育方面的广泛影响集中在它为来自代表性不足的群体的学生提供获得合成化学研究经验的机会。温斯顿塞勒姆州立大学为许多非裔美国人和少数族裔学生提供了通往科学的大门。通过这种方式，郭氏集团处于理想的位置，可以产生更广泛的重大教育影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Promoting the Diversity, Equity, and Inclusion in Organic Chemistry Education through Undergraduate Research Experiences at WSSU

DOI：
10.3390/educsci11080394
发表时间：
2021-08-01
期刊：
EDUCATION SCIENCES
影响因子：
3
作者：
Guo，Fenghai;Young，Jayla;Yakubu，Mamudu
通讯作者：
Yakubu，Mamudu

Conjugate Addition of Grignard Reagents to Thiochromones Catalyzed by Copper Salts: A Unified Approach to Both 2-Alkylthiochroman-4-One and Thioflavanone

铜盐催化格氏试剂与硫色酮的共轭加成：2-烷基硫色满-4-One 和硫黄烷酮的统一方法

DOI：
10.3390/molecules25092128
发表时间：
2020
期刊：
Molecules
影响因子：
4.6
作者：
Bellinger, Tania J.;Harvin, Teavian;Pickens-Flynn, Ti’Bran;Austin, Nataleigh;Whitaker, Samuel H.;Tang Yuk Tutein, Mai Ling;Hukins, Dabria T.;Deese, Nichele;Guo, Fenghai
通讯作者：
Guo, Fenghai