Characterization of metabolic networks in a microbial pathogen

微生物病原体代谢网络的表征

• 批准号: DP0878227
• 负责人: Dr Vladimir Likic
• 金额: $ 25.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878227
• 关键词: Characterization; metabolic; networks; microbial; pathogen

New methods are needed to understand complex cellular processes such as metabolism. This proposal will support the development of methods in metabolite profiling and flux analysis that provide a global view of metabolic networks in cells and complement other profiling approaches, such as proteomics and transcriptomics. The development of these approaches (collectively termed Systems Biology) is essential for maintaining Australia science at the forefront of international efforts (National Research Priority 3; Breakthrough science). This project will also directly contribute to our understanding of metabolism of an important human pathogen and provide training to young Australian scientists.

需要新的方法来理解复杂的细胞过程，如新陈代谢。该提案将支持代谢物分析和通量分析方法的发展，提供细胞代谢网络的全局视图，并补充其他分析方法，如蛋白质组学和转录组学。这些方法的发展（统称为系统生物学）对于保持澳大利亚科学在国际努力的前沿至关重要（国家研究重点3；突破性科学）。该项目还将直接有助于我们了解一种重要的人类病原体的代谢，并为年轻的澳大利亚科学家提供培训。