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New drugs and new targets: in search of new classes of drugs that inhibit rhodoquinone-dependent metabolism, an unusual form of anaerobic metabolism that allows parasites to survive in the human gut

New drugs and new targets: in search of new classes of drugs that inhibit rhodoquinone-dependent metabolism, an unusual form of anaerobic metabolism that allows parasites to survive in the human gut
新药和新靶标:寻找抑制罗多醌依赖性代谢的新型药物,这是一种不寻常的厌氧代谢形式,可让寄生虫在人体肠道中生存
批准号:
479299
负责人:
Fraser Andrew G
金额:
$73.56万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-03-01 至 2028-03-01

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中文摘要
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英文摘要
Soil-transmitted helminths (STHs) like hookworms infect over a billion people causing malnutrition and death, with the greatest effects on children. Drugs for treating STH infections exist but there are few such drugs and resistance to these is growing. I
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Using C.elegans to understand how the GAR-3 muscarinic acetylcholine receptor modulates other signaling pathways
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