I-Corps: Radiofrequency Ablation using Wirelessly Powered Catheter and Generator

I-Corps：使用无线供电导管和发生器进行射频消融

• 批准号: 1836894
• 负责人: Tsz Ho Tse
• 金额: $ 5万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1836894&HistoricalAwards=false
• 关键词: Corps; Radiofrequency; Ablation; using; Wirelessly

The broader impact/commercial potential of this I-Corps project centers around cancer treatment using wireless radiofrequency. Radiofrequency ablation is a minimally invasive procedure where surgeons burn tissue inside the body using electricity. Ablation treatment has been applied in several medical disciplines including oncology, cardiology, dermatology, pain management, etc.According to the National Cancer Institute, there were more than 1.6 million new cases of cancer in 2017 and approximately 600,000 cancer patients died. Many of these cancer patients can be treated with ablation therapy. A significant amount of funding is invested in cancer care, with $125 billion spent in 2010 alone; this number is estimated to reach $156 billion in 2020. Other diseases have similar numbers of affected patents and high amounts of care expenditures as well. This I-Corps program will provide opportunities for the team to explore various avenues for the commercialization of their wireless radiofrequency ablation technology that has broad application in many treatment areas.This I-Corps project is the first wireless radiofrequency ablation device designed to streamline and simplify the current ablation procedure. Using the principle of magnetic resonance, a wirelessly powered radiofrequency ablation device simply includes an ablation generator and a needle. The ablation generator serves as a transmitting circuit that wirelessly sends power to the needle's receiving coil. The receiving coil is connected to the electrodes at the needle tip that ablates tumor tissue in contact. Existing ablation methods have multiple wires tethered to the ablation equipment that limit the surgeon's dexterity to position the ablation needles during the procedure. The weight and dragging of the wires could increase patient setup time and cause potential tissue laceration. Also, a limited number of ablation needles can be used simultaneously, making it time consuming to ablate large tumors. This project's wireless ablation technology requires no wires and allows an unlimited number of ablation needles during the procedure. An initial prototype has been developed to prove the concept of wireless ablation and tests have been performed to prove the concept of the proposed technology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目的更广泛影响/商业潜力集中在使用无线射频的癌症治疗上。射频消融是一种微创手术，外科医生使用电流烧伤体内组织。消融治疗已应用于多个医学学科，包括肿瘤学、心脏病学、皮肤病学、疼痛管理等。根据美国国家癌症研究所的数据，2017年新增癌症病例超过160万例，约60万癌症患者死亡。许多癌症患者可以通过消融疗法进行治疗。大量资金投入到癌症治疗上，仅 2010 年就花费了 1,250 亿美元；预计到 2020 年，这一数字将达到 1560 亿美元。其他疾病也有类似数量的受影响专利和大量的护理支出。该 I-Corps 项目将为团队提供探索无线射频消融技术商业化的各种途径的机会，该技术在许多治疗领域具有广泛的应用。该 I-Corps 项目是第一个无线射频消融设备，旨在简化和简化当前的消融程序。利用磁共振原理，无线供电的射频消融装置仅包括消融发生器和针头。消融发生器充当发射电路，以无线方式向针的接收线圈发送电力。接收线圈连接到针尖处的电极，消融接触的肿瘤组织。现有的消融方法有多根电线拴在消融设备上，这限制了外科医生在手术过程中定位消融针的灵活性。电线的重量和拖拽可能会增加患者准备时间并导致潜在的组织撕裂。此外，可以同时使用的消融针数量有限，使得消融大肿瘤非常耗时。该项目的无线消融技术不需要电线，并且在手术过程中允许无限数量的消融针。已经开发出初始原型来证明无线消融的概念，并进行了测试来证明所提出的技术的概念。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。