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Phase II IUCRC at University of Illinois at Chicago: Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM)

Phase II IUCRC at University of Illinois at Chicago: Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM)
伊利诺伊大学芝加哥分校的 II 期 IUCRC:集成微流体先进设计与制造中心 (CADMIM)
批准号:
1841473
负责人:
Ian Papautsky
金额:
$50.0万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-03-01 至 2025-02-28

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中文摘要
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英文摘要
The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) develops technologies for integrating and manufacturing labs-on-a-chip (LOCs) for easy diagnosis of the human health, agriculture, and the environment. CADMIM emphasizes design-oriented research that anticipates the need for cost-effective manufacture and practical deployment, taking a broad integrated strategy that seeks breakthroughs at the interfaces of material science, engineering, biology, chemistry, and electronics in the development of next generation LOCs. These considerations early in the research and design cycle are key to transitioning technologies out of academic laboratories and into the manufacturing sector. Expected broader impacts include competitive recruitment mechanisms and attractive cross-disciplinary collaborative research opportunities to engage excellent students and post-docs, including members of underrepresented groups and veterans. Knowledge dissemination includes publications, invention disclosures, and patents. Scalable prototyping processes developed and/or adapted for microfluidics will also be made available to academia and industry, including established companies and entrepreneurs, with a goal to dramatically reduce the learning curve and streamline the idea-to-product process. This center will help catalyze the generation of new knowledge and pre-competitive research results to enable the development of microfluidics based technologies to enable industry to address pressing societal needs. The goal of this center is to develop technologies for integrating and manufacturing labs-on-a-chip (LOCs) for easy diagnosis of the human health, agriculture, and the environment. The strategy for meeting this goal centers on mass-produced diagnostic devices equipped with microfluidic components, chip-sized devices with high sensitivities (nM - pM) and short assay times ( 30 min) -- capable of chemical analyses in miniaturized volumes (ul - pl). The few available commercial microfluidic systems are expensive (costing up to hundreds of thousand dollars) and do not have effective sampling and analysis capability. What does not yet exist are mass-produced, cost-effective LOC platforms that integrate components to carry out multiple microfluidic/diagnostic functions and report results via a standard communications device. A primary obstacle is the lack of integration-enabling and manufacturable LOCs capable of processing real-world samples. Innovation is needed on two related fronts: (a) employing and/or modifying existing scalable processes make microfluidic devices, and (b) designing LOCs that are autonomous, field deployable, and amenable to mass production. By working closely with industrial member companies, CADMIM will make significant strides towards commercialization of microfluidic technology, leading to new products, the creation of new companies and/or new divisions within existing firms, new jobs, and other tangible commercial and societal impacts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
期刊论文(37)
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会议论文
Potentiometric Sensor System with Self-Calibration for Long-Term, In Situ Measurements
具有自校准功能的电位传感器系统,可进行长期原位测量
DOI: 10.3390/chemosensors11010048
发表时间: 2023
期刊: Chemosensors
影响因子: 4.2
作者: [Zhang, Zhehao, Boselli, Elena, Papautsky, Ian]
通讯作者: Papautsky, Ian
MULTIPLEXED, SELF-CALIBRATED POTENTIOMETRIC SENSOR SYSTEM FOR LONG-TERM, INSITU MEASUREMENTS
用于长期原位测量的多重自校准电位传感器系统
DOI: --
发表时间: 2022
期刊: Proceedings of the 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2022
影响因子: --
作者: [Zhang, Z., Boselli, E., Papautsky, I..]
通讯作者: Papautsky, I..
Physics of High-Viscosity Matrigel Droplet Generation
高粘度基质胶液滴生成的物理学
DOI: --
发表时间: 2022
期刊: IEEE EMBS Micro and Nanotechnology in Medicine Conference (MNMC
影响因子: --
作者: [Namasivayam, A., Hui, E.]
通讯作者: Hui, E.
DOI: 10.3390/mi11030287
发表时间: 2020-03-01
期刊: MICROMACHINES
影响因子: 3.4
作者: [Bogseth, Amanda, Zhou, Jian, Papautsky, Ian]
通讯作者: Papautsky, Ian
19
    I/UCRC: Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM)
    • 批准号:
      1738617
    • 项目类别:
      Continuing Grant
    • 资助金额:
      $13.52万
    • 财政年份:
      2016
    • 负责人:
      Ian Papautsky
    • 依托单位:
    I/UCRC: Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM)
    • 批准号:
      1362048
    • 项目类别:
      Continuing Grant
    • 资助金额:
      $30.0万
    • 财政年份:
      2014
    • 负责人:
      Ian Papautsky
    • 依托单位:
    Planning Grant: I/UCRC for Design and Advanced Manufacturing of Integrated Microfluidics for Ubiquitous Diagnostics
    Collaborative Research: Microfluidics for Multiple Engineering Disciplines
    • 批准号:
      0814911
    • 项目类别:
      Standard Grant
    • 资助金额:
      $11.95万
    • 财政年份:
      2008
    • 负责人:
      Ian Papautsky
    • 依托单位:
    国内基金
    海外基金
    基于生境成像与深度学习联合临床特征构建II型卵巢癌术前淋巴结转移预测模型的研究
    青蒿琥酯协同TROP2/线粒体级联靶向的NIR-II多模态诊疗用于晚期TNBC精准诊断与治疗的机制研究
    • 批准号:
      2026JJ30126
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      杨沙
    • 依托单位:
    鸡软骨非变性II型胶原高效制备和靶向递送的关键技术开发与应用示范
    苏合颗粒治疗慢性萎缩性胃炎的临床(II期)评价关键技术研究