Planning Grant: I/UCRC for Design and Advanced Manufacturing of Integrated Microfluidics for Ubiquitous Diagnostics

1266193加州大学欧文分校(UC-I)；亚伯拉罕·李1266195辛辛那提大学；Ian Papautsky拟建中心将开发能够进行多步骤生化评估的低功耗、自动化、自给自足、大规模生产的微型设备。加州大学欧文分校(UC-I)和辛辛那提大学(UCINN)正在合作建立拟议的中心，UCI是牵头机构。拟建中心的目标是开发先进制造技术，用于环境、农业和人类健康的无处不在的诊断和评估。拟建中心的目标将通过三个协调的基础和应用研究重点领域来实现：可制造工艺和材料、样品处理和检测以及集成和控制系统。该中心将产生以下成果：(A)可转让给工业利益攸关方用于产品开发的进步；(B)提供给政府实验室用于进一步特定用途开发的技术；以及(C)教育和培训一批擅长低成本可制造微流控生物芯片创新的专业科学家和工程师。更广泛的影响包括竞争性招聘机制和有吸引力的跨学科协作研究生研究机会，以吸引优秀学生，包括代表性不足群体的成员。除传统和会议外，知识传播还包括一个开放源码的“微流控函数库”，其中载有按应用和芯片制造工艺组织的微流控电路和可互换部件的设计规格。可扩展的原型过程还将传播给学术界和工业界，包括老牌公司和企业家，目标是大幅缩短学习曲线，并简化从想法到产品的过程。

1266193 University of California-Irvine (UC-I); Abraham Lee 1266195 University of Cincinnati; Ian Papautsky The proposed center will develop low-power, automated, self-contained, mass-produced micro-devices capable of multi-step biochemical assessments. University of California, Irvine (UC-I) and the University of Cincinnati (UCINN) are collaborating to establish the proposed center, with UCI as the lead institution. The goal of the proposed Center is to develop advanced manufacturing technologies for ubiquitious diagnostics and assessment of the environment, agriculture, and human health. The goals of this proposed Center will be achieved via three coordinated basic and applied research thrust areas: Manufacturable Processes and Materials, Sample Processing and Detection, and Integration and Control Systems. This Center would result in (a) advances that can be transferred to industrial stakeholders for product development, (b) technologies that feed into government laboratories for further application-specific development, and (c) the education and training of a cadre of specialized scientists and engineers skilled in low-cost manufacturable microfluidic biochip innovation. Broader impacts include competitive recruitment mechanisms and attractive cross-disciplinary collaborative graduate research opportunities to engage excellent students, including members of underrepresented groups. In addition to traditional and conferences, knowledge dissemination includes an open-source "microfluidic function library" containing design specifications for microfluidic circuits and interchangeable components organized by application and chip manufacturing processes. Scalable prototyping processes also will be disseminated to academia and industry, including established companies and entrepreneurs, with a goal to dramatically reduce the learning curve and streamline the idea-to-product process.