CAREER: Opposing roles of cortical input to dorsal striatum

为了感觉、思考、移动和学习，大脑的不同区域必须通过突触连接相互交流。大脑感觉和运动区之间的相互作用对于我们与周围世界的互动和反应尤为重要。然而，目前还不清楚来自大脑感觉区域的神经信号是如何直接影响与运动相关的大脑区域的。这项神经科学研究的目标是了解来自大脑皮层感觉和运动区的信号如何在被称为纹状体的重要皮质下区域内结合，以影响小鼠的决策行为。在小鼠身上进行这些研究，可以使用创新的神经科学技术，在突触、神经回路和行为水平上发现大脑功能的机制基础。该项目的课堂和宣传部分旨在以研究的技术和科学主题为基础。一门基于开源神经技术的大学课程将使学生能够流利地掌握现代实验神经科学和他们可以在职业生涯中使用的技能。该外展计划将通过与墨西哥研究人员的国际交流，以及通过在一本儿童科学期刊上发表双语出版物，来加强与代表性不足的少数族裔的联系。总而言之，这个项目将在多个层面上促进我们对大脑功能的理解和欣赏，从尖端的研究和教育到有益的社会推广。感觉和运动信息的整合对于区分不同的刺激和做出适当的动作至关重要。这个项目研究了大脑关键区域中的单个神经元和神经回路，如背侧纹状体，如何在行为表现和学习过程中动态处理感觉和运动输入。在小鼠胡须相关的躯体感觉系统中，初级感觉皮质(S1)和初级运动皮质(M1)的轴突投射在背侧纹状体水平结合，该结构因其通过影响运动丘脑而在行为中发挥作用而闻名。S1在纹状体功能中的作用，以及S1和M1的输入如何结合，目前尚不清楚。以往的工作大多集中在前额叶皮质对纹状体的输入，因此，我们对纹状体如何发生感觉-运动整合，以及它在行为和学习中的作用的理解还不完整。这个职业计划的目标是确定S1和M1传入背侧纹状体的神经回路，并确定它们在行为中的作用。这些结果将为了解S1和M1皮质纹状体信号在行为中的不同作用提供重要的知识。教育部分向本科生和研究生推广神经技术方面的专业知识，同时通过国际交流和以年轻人为重点的双语出版物，向未被充分代表的少数群体推广研究计划的基本要素。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

In order to feel, think, move, and learn, different areas of the brain must communicate with each other through synaptic connections. The interactions between sensory and motor areas of the brain are particularly important for interacting with and reacting to the world around us. However, it is still unknown exactly how neural signaling from the sensory areas of the brain directly influence brain areas related to movement. The goal of this neuroscientific study is to understand how signals from sensory and motor areas of the cerebral cortex combine within a important subcortical area called the striatum to influence decision-making behavior in mice. Conducting the studies in mice allows for the use of innovative neuroscience technology for discovering the mechanistic basis of brain function on the level of synapses, neural circuits, and behavior. Classroom and outreach components of the project are designed to build on the technological and scientific themes of the research. A university course based on open source neurotechnology will enable students to achieve fluency in modern experimental neuroscience and skills they can use throughout their careers. The outreach program will strengthen ties with underrepresented minorities through international exchange with researchers in Mexico and through bilingual publications in a scientific journal for kids. Together, this project will advance our understanding and appreciation of brain function on multiple levels, from cutting-edge research and education to beneficial societal outreach. The integration of sensory and motor information is critical for discriminating between different stimuli and making appropriate actions. This projects investigates how single neurons and neural circuits within key brain areas, such as the dorsal striatum, dynamically process sensory and motor input during behavioral performance and during learning. In the mouse whisker-related somatosensory system, axonal projections of primary sensory cortex (S1) and primary motor cortex (M1) combine at the level of the dorsal striatum, a structure known for its role in behavior through influence on the motor thalamus. The role of S1 in striatal function, and how S1 and M1 inputs combine, is unknown. Most previous work has focused on frontal cortex inputs to striatum, and therefore, our understanding of how sensorimotor integration takes place in striatum, and what its role is during behavior and learning are incomplete. The goal of this CAREER project is to determine the neural circuitries underlying S1 and M1 input to dorsal striatum, and to define their roles in behavior. The results will provide important knowledge of the distinct roles of S1- and M1-corticostriatal signaling in behavior. The education component promotes expertise in neurotechnology for undergraduate and graduate students, while outreach to underrepresented minorities builds on essential elements of the research program through international exchange and youth-focused bilingual publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.