Brown Adipose Tissue, Biological Variation and Senescence in Humans

人类棕色脂肪组织、生物变异和衰老

• 批准号: 1848330
• 负责人: Lynnette Leidy Sievert
• 金额: $ 23.07万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1848330&HistoricalAwards=false
• 关键词: Brown; Adipose; Tissue; Biological; Variation

Fundamental research in human biology includes efforts to understand the nature and tempo of human life history, including the timing and characteristics of aging in various physiological systems. This project focuses on hot flashes as an aspect of human variation during reproductive aging, and tests the hypothesis that brown adipose tissue - a type of fat that generates heat - may be a factor associated with hot flash experience. The study will extend our knowledge about human variation in both brown adipose tissue and hot flash experience, with particular attention to the relation between hot flashes (subjectively reported and biometrically measured), brown adipose tissue, body composition, and climate. The study will address human variation in the ability to generate and dissipate heat, and findings will contribute to knowledge about modern human biological adaptations. The outcomes of this research may also inform clinical understanding and treatments of conditions that affect many women in the U.S., including hot flashes and obesity. Results from this study will be shared with participants and communities through public talks, brochures and a project website. Undergraduate women will assist with the research, thereby gaining valuable experience in STEM fields. When brown adipose tissue is activated by cool or cold conditions, it creates heat in an effort to keep the body warm. The central hypothesis of this study is that brown adipose tissue activation may produce enough heat to cause hot flashes. The aim is to explore the role of brown adipose tissue activation in the experience of hot flashes among peri-menopausal and early postmenopausal women, aged 45-55, during the cold months -- from late October to early April -- in western Massachusetts. The investigators hypothesize that (1) women with more brown adipose tissue activity will be more likely to objectively demonstrate and subjectively report hot flashes, (2) brown adipose tissue activity is more likely to be associated with hot flashes in heavier women, and (3) acclimatization to heat and (4) exposure to lower ambient temperatures amplify the association between brown adipose tissue activity and hot flashes. The study involves face-to-face interviews about hot flashes and factors associated with hot flashes, physical activity, and stress; body measurements (height, weight, skinfolds, waist and hip circumferences); body composition by bioelectrical impedance; an estimation of brown adipose tissue activity with an infrared camera before and after dipping a hand into cool (64oF) water for five minutes; an ambulatory hot flash monitor worn for 24 hours to record both objective and subjective hot flashes; and an Actigraph GT9X watch to measure activity and sleep patterns for the same 24 hours. On the hot flash monitor pouch, there will also be a small ambulatory gauge to measure air temperature and humidity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类生物学的基础研究包括努力了解人类生命历史的性质和节奏，包括各种生理系统中衰老的时间和特征。该项目将潮热作为人类在生殖衰老过程中变化的一个方面，并测试了棕色脂肪组织--一种产生热量的脂肪--可能是与潮热体验相关的一个因素的假说。这项研究将扩展我们对棕色脂肪组织和潮热体验的人类变化的了解，特别关注潮热(主观报告和生物测量)、棕色脂肪组织、身体成分和气候之间的关系。这项研究将解决人类产生和散热能力的差异，研究结果将有助于了解现代人类的生物适应能力。这项研究的结果也可能有助于临床了解和治疗影响美国许多女性的疾病，包括潮热和肥胖。这项研究的结果将通过公开讲座、小册子和项目网站与参与者和社区分享。本科生女性将协助这项研究，从而获得STEM领域的宝贵经验。当棕色脂肪组织在凉爽或寒冷的条件下被激活时，它会产生热量，以努力保持身体温暖。这项研究的中心假设是，棕色脂肪组织的激活可能会产生足够的热量来引起潮热。其目的是探索棕色脂肪组织激活在马萨诸塞州西部寒冷的月份--10月底至4月初--围绝经期和绝经后早期女性(年龄在45-55岁)潮热体验中的作用。研究人员假设：(1)棕色脂肪组织活动较多的女性更有可能客观地表现出并主观地报告潮热，(2)在体重较重的女性中，棕色脂肪组织活动更有可能与潮热有关，(3)适应高温和(4)暴露在较低的环境温度下会放大棕色脂肪组织活动与潮热之间的联系。这项研究包括对潮热以及与潮热、体力活动和压力相关的因素进行面对面的采访；身体测量(身高、体重、皮褶、腰围和臀围)；通过生物电阻抗测量身体成分；用红外线相机估计手在凉水(64华氏度)中浸泡5分钟前后的棕色脂肪组织活动；佩戴24小时可移动的潮热监测器，记录客观和主观潮热；以及Actigraph GT9X手表，测量同样24小时的活动和睡眠模式。在热闪光监测袋上，还将有一个小型可移动测量仪来测量气温和湿度。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Sedentary Behavior Predicts Objectively Measured Hot Flashes in Midlife Women.

久坐行为可预测中年女性客观测量的潮热。

• 发表时间: 2021
• 期刊: Menopause
• 影响因子: 2.7
• 作者: Rickson, Jacquelyn J;Evard, Rose;Shreyer, Sofiya;Witkowski, Sarah;Brown, Daniel E;Sievert, Lynnette L.
• 通讯作者: Sievert, Lynnette L.

Stress and depressed mood increase the risk of night sweats, but not hot flashes, in menopausal women.

压力和抑郁情绪会增加更年期女性盗汗的风险，但不会增加潮热的风险。

• 发表时间: 2023
• 期刊: American journal of human biology
• 影响因子: 2.9
• 作者: Shreyer, Sofiya I;Sievert, Lynnette L;Brown, Daniel E.
• 通讯作者: Brown, Daniel E.

Hot Bods: Body composition and frequency of hot flashes.

热体：身体成分和潮热频率。

• 发表时间: 2022
• 期刊: American journal of human biology
• 影响因子: 2.9
• 作者: Shreyer, SS;Sievert, LL;Brown DE.
• 通讯作者: Brown DE.

Physical Activity Intensity Predicts Objective but Not Subjective Hot Flash Experience.

身体活动强度可以预测客观而非主观的潮热体验。

• 发表时间: 2021
• 期刊: Menopause
• 影响因子: 2.7
• 作者: Evard, Rose;Rickson, Jacquelyn;Shreyer, Sofiya;Witkowski, Sarah;Brown, Daniel E;Sievert, Lynnette L.
• 通讯作者: Sievert, Lynnette L.

Varying impacts of hot flashes and night sweats on depression and stress.

潮热和盗汗对抑郁和压力的影响各不相同。

• 发表时间: 2022
• 期刊: Menopause
• 影响因子: 2.7
• 作者: Shreyer, Sofiya S;Sievert, Lynnette L;Brown, Daniel E.
• 通讯作者: Brown, Daniel E.