REU Site: Functional Genomics Research for Undergraduates

REU 网站：本科生功能基因组学研究

• 批准号: 1851697
• 负责人: Charles Wray
• 金额: $ 45.66万
• 依托单位: Jackson Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1851697&HistoricalAwards=false
• 关键词: REU; Site; Functional; Genomics; Research

This REU Site award to the Jackson Laboratory (JAX), located in Bar Harbor, ME, will support the training of 12 students for 10 weeks during the summers of 2019-2021. Undergraduates will conduct original research in mammalian functional genomics with a faculty mentor at JAX. Student research will expand their basic understanding of how an organism's genome determines its development and biological function. To prepare for genomics research, students will have access to online modules prior to and during their fellowship, will complete workshops in computational methods and bioinformatics, and will attend seminars to prepare them for graduate education and a career in genomics. Students will increase their self-confidence and build their network within a learning community that is part of the long-standing JAX Summer Student Program, including a shared on-campus residential program. The REU Site recruits undergraduate students at all levels. The goal is to develop a diverse community of learners including individuals from groups underrepresented in science, such as racial and ethnic minorities, people with disabilities, and people with a significant socioeconomic or educational disadvantage, including first-generation college students. It is anticipated that a total of 12 students, primarily from schools with limited research opportunities, will be trained in the program. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. Students trained in genomics will become more versatile, be able to work in teams with the potential for higher impact research. REU students at JAX will become better communicators and more aware of the ethical, legal, and social responsibilities of genomics scientists. A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after the program in order to determine their career paths. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the JAX program is available by visiting https://www.jax.org/ssp, or by contacting the PI (Dr. Linda Hicke, [e-mail]) or the Program Director (Michael McKernan, [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个REU网站奖给杰克逊实验室（JAX），位于巴尔港，ME，将支持12名学生在2019年至2021年的夏天10周的培训。本科生将与JAX的教师导师一起进行哺乳动物功能基因组学的原创研究。学生的研究将扩大他们对生物体的基因组如何决定其发育和生物功能的基本理解。为了准备基因组学研究，学生将有机会获得在线模块之前和期间他们的奖学金，将完成计算方法和生物信息学的研讨会，并将参加研讨会，以准备他们的研究生教育和基因组学的职业生涯。学生将增加他们的自信心，并在一个学习社区内建立自己的网络，这个学习社区是长期的JAX暑期学生计划的一部分，包括一个共享的校园住宿计划。REU网站招收所有级别的本科生。目标是发展一个多元化的学习者社区，包括来自科学领域代表性不足的群体的个人，如种族和少数民族，残疾人，以及社会经济或教育方面处于显著劣势的人，包括第一代大学生。预计共有12名学生，主要来自研究机会有限的学校，将接受该方案的培训。学生将学习如何进行研究，许多人将在科学会议上展示他们的工作成果。接受基因组学培训的学生将变得更加多才多艺，能够在团队中工作，具有更高影响力的研究潜力。在JAX的REU学生将成为更好的沟通者，更了解基因组学科学家的道德，法律的和社会责任。由生物基础设施部资助的所有REU研究中心项目使用的通用网络评估工具将用于确定培训项目的有效性。学生将在课程结束后进行跟踪，以确定他们的职业道路。学生将被要求通过NSF报告系统自动发送电子邮件。有关JAX计划的更多信息，请访问https：//www.jax.org/ssp，或联系PI（琳达·希克博士，linda. jax.org）或计划总监（迈克尔·麦克尔南，michael. jax.org）。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots

• DOI: 10.1101/gad.333542.119
• 发表时间: 2020-03-01
• 期刊: GENES & DEVELOPMENT
• 影响因子: 10.5
• 作者: Spruce，Catrina;Dlamini，Sibongakonke;Baker，Christopher L.
• 通讯作者: Baker，Christopher L.