High-Performance Panoptic Mass Spectrometry for Electrocatalytic Reaction Screening

用于电催化反应筛选的高性能全景质谱仪

• 批准号: 1900271
• 负责人: Abraham Badu-Tawiah
• 金额: $ 45万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900271&HistoricalAwards=false
• 关键词: Performance; Panoptic; Mass; Spectrometry; Electrocatalytic

In this project funded by the Chemical Structure, Dynamics, and Mechanisms-B and Chemical Measurement and Imaging Programs, Professor Abraham Badu-Tawiah of the Department of Chemistry and Biochemistry at Ohio State University is developing a new electrocatalytic screening platform for the selective reactions (oxidation) of carbon carbon double bonds. The project seeks to identify electrocatalytic conditions that enable selective synthesis of high-value fine chemicals. Education and outreach activities are designed to directly impact students in the early stages (K-12) of their educational experience. The project is well-positioned to introduce students - including groups underrepresented in the STEM fields - to interdisciplinary science. The majority of heterogeneous electrocatalysts are oxides or metals dispersed onto oxide supports. Traditionally, oxide synthesis and subsequent reactivity screening occur separately in two independent experiments. This project targets an all-in-one panoptic system that combines in-situ oxide synthesis and catalytic reaction screening into a single experimental step. The research involves the development of a multimodal, contained, nano-electrospray system for the in-situ preparation of the eletrocatalyst and subsequent modification of the reaction environment in real-time. Anodic reaction screening is investigated using the electrooxidation of alkenes by non-inert metal electrodes to produce several important reactive chemical intermediates. Cathodic reaction screening is showcased using the selective reduction of carbon carbon double bonds in the presence of carbon oxygen double bonds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由化学结构、动力学和机制-B以及化学测量和成像计划资助的项目中，俄亥俄州立大学化学和生物化学系的Abraham Badu-Tawiah教授正在为碳-碳双键的选择性反应(氧化)开发一个新的电催化筛选平台。该项目寻求确定能够选择性合成高价值精细化学品的电催化条件。教育和外展活动旨在直接影响学生在其教育经历的早期阶段(K-12)。该项目很好地将学生--包括在STEM领域代表性不足的群体--介绍给跨学科的科学。大多数多相电催化剂是分散在氧化物载体上的氧化物或金属。传统上，氧化物合成和随后的反应性筛选分别在两个独立的实验中进行。该项目的目标是将原位氧化物合成和催化反应筛选结合到一个单一的实验步骤中的一体化全景系统。这项研究涉及开发一种多模式、包含的纳米电喷雾系统，用于原位制备电催化剂并随后实时修改反应环境。利用非惰性金属电极对烯烃的电氧化反应进行阳极反应筛选，生成几种重要的活性化学中间体。阴极反应筛选是在碳氧双键存在的情况下选择性地还原碳碳双键。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Uncatalyzed N-Alkylation of Amines in Ionic Wind from Ambient Corona Discharge

• DOI: 10.1021/acs.analchem.0c04440
• 发表时间: 2021-01-04
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Lee, Suji;Kulyk, Dmytro S.;Badu-Tawiah, Abraham K.
• 通讯作者: Badu-Tawiah, Abraham K.

In-Source Microdroplet Derivatization Using Coaxial Contained-Electrospray Mass Spectrometry for Enhanced Sensitivity in Saccharide Analysis

• DOI: 10.1021/acs.analchem.1c02897
• 发表时间: 2021-12-07
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Heiss, Derik R.;Badu-Tawiah, Abraham K.
• 通讯作者: Badu-Tawiah, Abraham K.

Spray Mechanism of Contained-Electrospray Ionization

封闭式电喷雾电离喷雾机理

• DOI: 10.1021/jasms.0c00044
• 发表时间: 2020
• 期刊: Journal of the American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: Miller, Colbert F.;Burris, Benjamin J.;Badu-Tawiah, Abraham K.
• 通讯作者: Badu-Tawiah, Abraham K.

High-Throughput Mass Spectrometry Screening Platform for Discovering New Chemical Reactions under Uncatalyzed, Solvent-Free Experimental Conditions

• DOI: 10.1021/acs.analchem.0c02960
• 发表时间: 2020-11-17
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Kulyk, Dmytro S.;Amoah, Enoch;Badu-Tawiah, Abraham K.
• 通讯作者: Badu-Tawiah, Abraham K.