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Studying the Processes of Assembly and Stimuli-Responsive Morphological Transformations in Solvated Macromolecular Nano-Assemblies

研究溶剂化大分子纳米组装体的组装过程和刺激响应形态转变

基本信息

批准号：
1905270
负责人：
Nathan Gianneschi
金额：
$ 60万
依托单位：
Northwestern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1905270&HistoricalAwards=false
关键词：
Studying Processes Assembly Stimuli Responsive

项目摘要

With funding from the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Nathan Gianneschi of Northwestern University and Lucas R. Parent of University of Connecticut examine how amphiphilic copolymers behave in water on the nanoscale. Amphiphilic copolymers are long chain molecules possessing both water-loving and oil-loving properties. Examples of common amphiphilic compounds include soaps and detergents. In this work, electron microscopy is used to observe molecular-scale movement during the self-assembly of amphiphilic copolymers in water. Experimental studies examine the pathways and intermediates for the assembly. Control of self-assembly has promise for applications such as optimized drug or cosmetic delivery vehicles, as functionalelements in composites, as optical sensors, and in the transport of catalysts and reagents in industry and biology. Beyond research and mentoring in a laboratory, this project connects with ongoing school outreach efforts. Activities include Exploring Engineering and Spark annual summer camps for national STEM high school students and local middle school girls. Also, the da Vinci Program is designed to educate local secondary school teachers and administrators on increasing classroom STEM education.This work employs in situ liquid phase transmission electron microscopy techniques to study the dynamic processes of macromolecular nanostructures involving copolymers of N,N-dimethylacrylamide, N-isopropylacrylamide and/or n-butyl acrylate. Particular emphasis is placed on developing an understanding of the mechanisms and pathways of self-assembly/disassembly, kinetic trapping, phase changes and morphological transformations. Polymer syntheses are conducted using reversible addition-fragmentation transfer polymerization which enables control over molecular weight and polydispersity. Understanding control at the nanoscale has promise for the application of investigated amphiphilic copolymers as components capable of performing as optimized drug delivery vehicles and as functional elements in composites capable of mechanical or rheological responses. Additionally, such systems also have the potential to transport catalysts and reagents. Research associated with this award advances understanding of the fundamental process of self-assembly of discrete architectures from disperse polymers which is of significant interest not only to nanoscience community, but to polymer scientists in general.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子、超分子和纳米化学项目的资助下，西北大学的内森·詹内斯基和卢卡斯·R·卡耐基（Lucas R.康涅狄格大学的家长研究了两亲性共聚物在纳米级水中的行为。两亲性共聚物是一类兼具亲水性和亲油性的长链分子。常见的两亲性化合物的实例包括肥皂和洗涤剂。在这项工作中，电子显微镜是用来观察分子尺度的运动过程中的两亲性共聚物在水中的自组装。实验研究检查组装的途径和中间体。自组装的控制有希望的应用，如优化药物或化妆品输送车辆，作为复合材料中的功能元件，作为光学传感器，以及在工业和生物学中的催化剂和试剂的运输。除了在实验室进行研究和指导外，该项目还与正在进行的学校外展工作相联系。活动包括为全国STEM高中学生和当地中学女生举办的探索工程和火花年度夏令营。此外，芬奇计划的目的是教育当地的中学教师和管理人员增加课堂STEM教育。这项工作采用原位液相透射电子显微镜技术，研究涉及N，N-二甲基丙烯酰胺，N-异丙基丙烯酰胺和/或丙烯酸正丁酯共聚物的大分子纳米结构的动态过程。特别强调的是发展自我组装/拆卸，动力学捕获，相变和形态转变的机制和途径的理解。聚合物合成使用可逆加成-断裂转移聚合进行，其能够控制分子量和多分散性。了解控制在纳米尺度上的应用有希望的调查两亲性共聚物的组件能够执行作为优化的药物输送车辆和功能元件的复合材料能够机械或流变反应。此外，这种系统还具有输送催化剂和试剂的潜力。与该奖项相关的研究促进了对分散聚合物自组装的基本过程的理解，这不仅对纳米科学界，而且对一般聚合物科学家都具有重大意义。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。