NSF Postdoctoral Fellowship in Biology FY 2019: Trait Stability and Broad Adaptation over Forty Years of Selection in a Global Wheat Breeding Program

2019 财年 NSF 生物学博士后奖学金：全球小麦育种计划四十年选择中的性状稳定性和广泛适应性

• 批准号: 1907296
• 负责人: Margaret Krause
• 金额: $ 21.6万
• 依托单位: Krause, Margaret Rose
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1907296&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF National Plant Genome Initiative Postdoctoral Research Fellowship in Biology for FY 2019. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Margaret R. Krause is "Trait Stability and Broad Adaptation over Forty Years of Selection in a Global Wheat Breeding Program". The host institutions for the fellowship are the International Maize and Wheat Improvement Center (CIMMYT)/Kansas State University, and the sponsoring scientists are Drs. Matthew Reynolds and Jesse Poland. Crop varieties that maintain consistent yields across a range of environmental stresses are of value to farmers, particularly those who are resource-poor with limited ability to recover from crop losses. Understanding the genetic basis of trait stability across a gradient of environmental conditions will enhance the development of broadly adapted, climate-resilient crop varieties. However, trait stability is expensive and laborious to measure due to the extensive multi-environment trials required to produce reliable estimates. Since 1979, the International Maize and Wheat Improvement Center (CIMMYT) in Mexico has sent wheat breeding material to collaborators around the world for evaluation each year. These trials provide a rare opportunity to improve our understanding of 1) the genetic controls underlying trait stability in wheat and 2) how the wheat genome has evolved over forty years of selection for broad adaptation. Broader impacts include developing data analytics training modules for plant breeders from developing countries. Training objectives includes acquiring expertise in genomics and bioinformatics at Kansas State University, and in the analysis of weather datasets at CIMMYT's research center at Henan Agricultural University in China. The project will integrate genomic information, weather data, and phenotypic trait records from forty years of CIMMYT's international trials to understand the genetic architecture of phenotypic stability and the effects of long-term artificial selection for broad adaptation on the wheat genome. The project will develop robust estimates of stability for yield and other traits from data records that were collected at more than 500 locations ranging from Norway to New Zealand and spanning more than 3,500 meters in elevation. The project will also generate whole genome re-sequencing of CIMMYT's founder lines and weather datasets linked to the international trial locations. Data and methodologies will be made publically available in peer reviewed journal articles, on CIMMYT's Research Data & Software Repository Network (https://data.cimmyt.org/), and through Dataverse, an open source public data repository (dataverse.org).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

本行动资助NSF国家植物基因组计划2019财年生物学博士后研究奖学金。该奖学金支持奖学金获得者在主办实验室的研究和培训计划，该奖学金获得者还提出了扩大生物学参与的计划。为玛格丽特·r·克劳斯（Margaret R. Krause）提供的研究和培训计划的标题是“全球小麦育种计划40年来选择的性状稳定性和广泛适应性”。该奖学金的主办机构是国际玉米和小麦改良中心(CIMMYT)/堪萨斯州立大学，赞助科学家是博士。马修·雷诺兹和杰西·波兰。在各种环境压力下保持一致产量的作物品种对农民，特别是对那些资源贫乏、从作物损失中恢复能力有限的农民来说是有价值的。了解不同环境条件下性状稳定性的遗传基础将促进广泛适应和气候适应型作物品种的发展。然而，由于需要进行广泛的多环境试验来产生可靠的估计，性状稳定性的测量既昂贵又费力。自1979年以来，墨西哥的国际玉米和小麦改良中心（CIMMYT）每年向世界各地的合作者发送小麦育种材料进行评估。这些试验提供了一个难得的机会来提高我们对以下方面的理解：1)小麦性状稳定性的遗传控制；2)小麦基因组是如何在40多年的选择中进化为广泛适应的。更广泛的影响包括为发展中国家的植物育种者开发数据分析培训模块。培训目标包括在堪萨斯州立大学获得基因组学和生物信息学方面的专业知识，以及在中国河南农业大学CIMMYT研究中心获得天气数据集分析方面的专业知识。该项目将整合来自CIMMYT 40年国际试验的基因组信息、天气数据和表型性状记录，以了解表型稳定性的遗传结构以及长期人工选择对小麦基因组广泛适应的影响。该项目将根据从挪威到新西兰、海拔超过3500米的500多个地点收集的数据记录，对产量和其他性状的稳定性进行可靠的估计。该项目还将生成CIMMYT始祖系的全基因组重测序以及与国际试验点相关的天气数据集。数据和方法将在同行评议的期刊文章、CIMMYT的研究数据和软件存储库网络（https://data.cimmyt.org/）以及开源公共数据存储库Dataverse （dataverse.org）上公开。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。