Phase II IUCRC at UC San Francisco: Center for Disruptive Musculoskeletal Innovations (CDMI)

加州大学旧金山分校的第二阶段 IUCRC：破坏性肌肉骨骼创新中心 (CDMI)

• 批准号: 1916629
• 负责人: Jeffrey Lotz
• 金额: $ 50万
• 依托单位: University of California-San Francisco
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1916629&HistoricalAwards=false
• 关键词: Phase; II; IUCRC; UC; San

Human life is characterized by physical movement. Yet, a growing number of adults are disabled by joint pain that regularly limits their physical activity. Musculoskeletal disorders (MSDs) encompass degenerative, inflammatory and developmental conditions, injury, and overuse. The personal impact ranges from devastating effects on health to subtle reductions in quality of life. MSDs affect more than half of the US adult population, and 75% of those over age 65. The mission of the Center for Disruptive Musculoskeletal Innovations (CDMI) is to address pressing societal needs associated with the growing burden of MSDs. Priority CDMI research themes include: characterizing MSD causal pathways; developing tools for MSD risk assessment, diagnosis, and functional recovery; predictive analytics for clinical care management; medical device design and testing; and clinical outcomes assessment with an emphasis on cost/benefit and patient value. Our goal is to generate data on incidence, pathomechanisms, treatment outcomes, and costs associated with MSDs, and based on these data, develop new technologies for MSD prevention, diagnosis, and treatment. Collectively, these efforts will result in healthier Americans and a stronger and more-competitive U.S. economy.The CDMI has strategically joined four academic sites that integrate expertise in: Musculoskeletal disorder (MSD) causal pathways, tools for MSD risk assessments, biomechanical models, and bioengineering (The Ohio State University - OSU); MSD biology, diagnostics, clinical cohorts, digital health, and clinical data analytics (University of California, San Francisco - UCSF); Medical device design, computational modeling, empirical testing, and testing standards (University of Toledo - UT); and Advanced materials, sensors, and chemical engineering (affiliate site Northeastern University - NU). The UCSF site focuses on digital health technologies and solutions, regenerative therapies, clinical data analytics, and development of diagnostic tools that help better match patients to treatments and better quantify patient response to therapy. UT research centers on development of devices, biomaterials, and clinical assessment of surgical procedures. OSU applies its sensitive risk exposure tools and person-specific biomechanical models to clarify how physical, psychological, psychosocial, and personal risk factors influence injury risk. The CDMI Research Roadmap identifies high priority areas for project proposal solicitation. These include basic science, biomaterials, clinical outcomes (including digital health), SMART devices, development/assessment of innovative devices/surgical techniques/instruments, healthcare economics, osteoporosis, soft tissue repair, patient assessment tools, test method development, MSD casual pathways, MSD risk assessments, and injury prevention.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类的生活是以身体运动为特征的。然而，越来越多的成年人因关节疼痛而致残，这种疼痛经常限制他们的体力活动。肌肉骨骼疾病(MSD)包括退行性、炎症和发育状况、损伤和过度使用。对个人的影响从对健康的破坏性影响到生活质量的微妙下降。MSD影响了超过一半的美国成年人，以及75%的65岁以上的人。颠覆性肌肉骨骼创新中心(CDMI)的使命是解决与MSD日益沉重的负担相关的紧迫社会需求。CDMI的优先研究主题包括：确定MSD因果路径的特征；开发用于MSD风险评估、诊断和功能恢复的工具；用于临床护理管理的预测性分析；医疗设备设计和测试；以及注重成本/效益和患者价值的临床结果评估。我们的目标是生成与MSD相关的发病率、发病机制、治疗结果和成本的数据，并基于这些数据开发用于MSD预防、诊断和治疗的新技术。CDMI战略性地加入了四个整合了以下专业知识的学术网站：肌肉骨骼疾病(MSD)因果路径、MSD风险评估工具、生物力学模型和生物工程(俄亥俄州立大学-俄亥俄州立大学)；MSD生物学、诊断、临床队列、数字健康和临床数据分析(加州大学旧金山分校)；医疗器械设计、计算建模、经验测试和测试标准(托莱多大学-UT)；以及先进材料、传感器和化学工程(附属网站东北大学-NU)。加州大学旧金山分校的网站专注于数字健康技术和解决方案、再生疗法、临床数据分析以及诊断工具的开发，以帮助患者更好地匹配治疗并更好地量化患者对治疗的反应。UT的研究集中在设备、生物材料的开发和外科手术的临床评估上。OSU应用其敏感的风险暴露工具和特定于个人的生物力学模型来阐明身体、心理、心理社会和个人风险因素如何影响受伤风险。CDMI研究路线图确定了项目建议书征集的高度优先领域。这些奖项包括基础科学、生物材料、临床成果(包括数字健康)、智能设备、创新设备/外科技术/工具的开发/评估、医疗保健经济学、骨质疏松症、软组织修复、患者评估工具、测试方法开发、MSD临时路径、MSD风险评估和伤害预防。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

NanoSUS (Ultra Fine Grained Stainless-Steel) for Percutaneous Spinal Injection

用于经皮脊柱注射的 NanoSUS（超细晶粒不锈钢）

• 发表时间: 2019
• 作者: Bahram Saleh, Caterina Bartomeu

Reachable Workspace and Proximal Function Measures for Quantifying Upper Limb Motion

• DOI: 10.1109/jbhi.2020.2989722
• 发表时间: 2020-11-01
• 期刊: IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
• 影响因子: 7.7
• 作者: Matthew, Robert P.;Seko, Sarah;Lotz, Jeffrey
• 通讯作者: Lotz, Jeffrey

Developing Bioactive-Nanograined Metals With Bacterial Biofilm Inhibition Properties For Orthopedic Devices

为骨科器械开发具有细菌生物膜抑制特性的生物活性纳米颗粒金属

• 发表时间: 2021
• 期刊: Orthopaedic Research Society
• 作者: Kelkar, Shaunak;Saleh, Bahram;Yusa, Fumie;Suzuki, Yohei;Komatsu, Takafumi;Webster, Thomas
• 通讯作者: Webster, Thomas

NanoSUS (Ultra Fine Grained Stainless-Steel) for Orthopedic Implants

用于骨科植入物的 NanoSUS（超细晶粒不锈钢）

• 发表时间: 2021
• 期刊: Orthopaedic Research Society
• 作者: Bahram Saleh, Ada Vernet-Crua

Nano SUS (Ultra Fine Grained Stainless-Steel) for Orthopedic Implants

用于骨科植入物的纳米 SUS（超细晶粒不锈钢）

• 发表时间: 2020
• 期刊: American Institute of Chemical Engineers Conference
• 作者: Shaunak Kelkar, Bahram Saleh