Collaborative Research: Impacts of Metals on Disinfection Byproduct Precursor Formation in Bacteria
合作研究:金属对细菌中消毒副产物前体形成的影响
基本信息
- 批准号:1917057
- 负责人:
- 金额:$ 20.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Potable water supplies must be disinfected to protect human health. However, disinfectants can interact with organic matter in the system to cause the formation of byproducts that pose risks to human health. Understanding the disinfection byproduct formation process is a critical need for water utilities and regulatory agencies to reduce risk. This project addresses this national need by investigating how trace metals influence disinfection byproduct formation in water distribution systems. The underlying hypothesis is that exposure of biofilm microbes in the distribution system to heavy metals results in the release of small organic molecules. These molecules can then serve as the building blocks of disinfection byproducts through chemical reaction with disinfectants. This project establishes a research and education partnership between Oklahoma State University and Syracuse University at the interface of environmental microbiology and environmental chemistry. A STEM educational outreach program for elementary school students and provide summer internship research opportunities for high school students. This effort will improve the scientific literacy of the Nation and increase the capability of the STEM workforce to meet societal needs for clean and sustainable water. Disinfection byproducts are formed upon reactions of organic matter with disinfectants during water treatment. Strategies to control disinfection byproduct formation focus on removing their precursors prior to disinfection or removing disinfection byproducts after they have formed in the water treatment plant. Unfortunately, disinfection byproducts continue to form within distribution systems when precursors released by biofilms in the distribution system react with residual disinfectant. Bacterial metabolic processes and cellular regulation are highly sensitive to concentrations of trace metals, which vary significantly in distribution systems. The overall goal of this research is to characterize how trace metals affect the production of disinfection byproduct precursors from biofilms under conditions relevant to chloraminated drinking water distribution networks. The central hypothesis is that exposure to varying types and concentrations of trace metals alters metabolic pathways in biofilm microorganisms, resulting in shifts in the composition and reactivity of disinfection byproduct precursors released by the bacteria. The specific research objectives of this project are to: 1) examine the influence of metals on disinfection byproduct formation potential from bacterial isolates, 2) characterize the effects of metal exposure on changes in the composition and reactivity of biofilm-derived disinfection byproduct precursors, and 3) determine the underlying mechanisms of increased disinfection byproduct formation potential in bacterial isolates and biofilms through transcriptomic and proteomic approaches. This research addresses gaps in knowledge and model formulations with regards to predicting disinfection byproduct precursor loadings contributed by biofilms in chloraminated distribution systems. This research will provide a more complete understanding of the impacts that changes in metal speciation and concentration have on disinfection byproduct formation potential in full-scale distribution systems. The team will recruit underrepresented minority students to summer research positions to increase the diversity of STEM fields and outreach to the public will take place through seminars on safe drinking water.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
饮用水供应必须消毒以保护人体健康。然而,消毒剂可以与系统中的有机物相互作用,导致形成对人体健康构成威胁的副产物。了解消毒副产物的形成过程对水务公司和监管机构降低风险至关重要。该项目通过调查微量金属如何影响配水系统中消毒副产物的形成来解决这一国家需求。潜在的假设是,分配系统中的生物膜微生物暴露于重金属会导致小有机分子的释放。这些分子可以通过与消毒剂的化学反应作为消毒副产物的基本成分。该项目建立了俄克拉荷马州立大学和锡拉丘兹大学在环境微生物学和环境化学领域的研究和教育合作伙伴关系。一项针对小学生的STEM教育推广计划,并为高中生提供暑期实习研究机会。这项工作将提高国家的科学素养,提高STEM劳动力的能力,以满足社会对清洁和可持续水的需求。消毒副产物是水处理过程中有机物与消毒剂反应形成的。控制消毒副产物形成的策略侧重于在消毒前去除其前体或在水处理厂中形成消毒副产物后去除其。不幸的是,当分配系统中的生物膜释放的前体与残留的消毒剂发生反应时,消毒副产物继续在分配系统中形成。细菌代谢过程和细胞调节对微量金属的浓度高度敏感,这些浓度在分布系统中变化很大。本研究的总体目标是表征在与氯胺化饮用水分配网络相关的条件下,微量金属如何影响生物膜消毒副产物前体的生产。核心假设是,暴露于不同类型和浓度的微量金属会改变生物膜微生物的代谢途径,导致细菌释放的消毒副产物前体的组成和反应性发生变化。该项目的具体研究目标是:1)研究金属对细菌分离物消毒副产物形成电位的影响;2)表征金属暴露对生物膜衍生的消毒副产物前体组成和反应性变化的影响;3)通过转录组学和蛋白质组学方法确定细菌分离物和生物膜中消毒副产物形成电位增加的潜在机制。本研究解决了关于预测氯胺化分配系统中生物膜贡献的消毒副产物前体负荷的知识和模型配方方面的差距。这项研究将提供一个更完整的了解,金属形态和浓度的变化对消毒副产物形成潜力的影响,在全面的分配系统。该团队将招募代表性不足的少数族裔学生担任暑期研究职位,以增加STEM领域的多样性,并将通过安全饮用水研讨会向公众宣传。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Teng Zeng其他文献
ITO基质上BiPO4薄膜的光电催化降解作用
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:3.8
- 作者:
Teng Zeng;Yi Zhu;Yuanming Zhang - 通讯作者:
Yuanming Zhang
Joint Mobility and Vehicle-to-Grid Coordination in Rebalancing Shared Mobility-on-Demand Systems
重新平衡共享移动按需系统中的联合移动和车辆到电网协调
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Teng Zeng;Scott J. Moura;Zhe Zhou - 通讯作者:
Zhe Zhou
Clustering chlorine reactivity of haloacetic acid precursors in inland lakes.
内陆湖泊卤乙酸前体的氯反应活性聚类。
- DOI:
10.1021/es403766n - 发表时间:
2014 - 期刊:
- 影响因子:11.4
- 作者:
Teng Zeng;W. Arnold - 通讯作者:
W. Arnold
Modeling and mechanism of the adsorption of proton onto natural bamboo sawdust
- DOI:
10.1016/j.carbpol.2011.08.098 - 发表时间:
2012-01-15 - 期刊:
- 影响因子:
- 作者:
Xue-Tao Zhao;Teng Zeng;Zhang Jun Hu;Hong-Wen Gao;Cong Yang Zou - 通讯作者:
Cong Yang Zou
LINC00662 regulates osteogenic differentiation of BMSCs and inhibits fracture healing via miR-330-3p/PTEN axis
- DOI:
10.1186/s12891-025-08845-z - 发表时间:
2025-07-04 - 期刊:
- 影响因子:2.400
- 作者:
Jiawei Gong;Jiehua Luo;Teng Zeng;Liping Zhu;Huasong Luo;Kun Ding;Mohamed Lamin Bangura;Jinliang Ma;Yunfeng Lv - 通讯作者:
Yunfeng Lv
Teng Zeng的其他文献
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{{ truncateString('Teng Zeng', 18)}}的其他基金
CAREER: Impacts of Lake Browning on the Photochemical Fate of Organic Micropollutants
职业:布朗宁湖对有机微污染物光化学归宿的影响
- 批准号:
2145214 - 财政年份:2022
- 资助金额:
$ 20.97万 - 项目类别:
Continuing Grant
MRI: Acquisition of a Liquid Chromatograph-High Resolution Mass Spectrometer to Characterize Organic Molecules of Environmental and Health Significance
MRI:获取液相色谱-高分辨率质谱仪来表征具有环境和健康意义的有机分子
- 批准号:
2018497 - 财政年份:2020
- 资助金额:
$ 20.97万 - 项目类别:
Standard Grant
Secondary Amine-Containing Organic Micropollutants as Precursors of Previously Uncharacterized N-Nitrosamines in Wastewater
含有仲胺的有机微污染物是废水中先前未表征的 N-亚硝胺的前体
- 批准号:
1927930 - 财政年份:2019
- 资助金额:
$ 20.97万 - 项目类别:
Standard Grant
EAGER: PPER Citizen Science-Based Monitoring Framework for Contaminants of Emerging Concern in New York State Lakes
EAGER:PPER 基于公民科学的纽约州湖泊新兴污染物监测框架
- 批准号:
1743988 - 财政年份:2017
- 资助金额:
$ 20.97万 - 项目类别:
Standard Grant
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Research on Quantum Field Theory without a Lagrangian Description
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- 项目类别:省市级项目
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- 批准号:31224802
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Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
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