Analysis of the activation of chloroplast translation and RNA stabilization by PPR proteins and PPR protein derived sRNAs

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PPR proteins are essential for all steps in chloroplast RNA metabolism and thus for chloroplast biogenesis. Each PPR protein binds with high selectivity to just a few plastid RNAs. A subset of PPR proteins impacts the stability and translation of mRNAs. These PPR proteins cause footprints that accumulate as short RNAs (sRNAs). This proposal has two main goals: 1. Understanding the mechanistic details of how PPR proteins activate translation and how they stabilize mRNAs. 2. Understanding the role of sRNAs as potential regulators of chloroplast gene expression.