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MRI: Acquisition of a Fully-Motorized Research Microscope at Fairfield University Project Description

MRI：在费尔菲尔德大学购买全电动研究显微镜项目描述

基本信息

批准号：
1919646
负责人：
Anita Fernandez
金额：
$ 17.54万
依托单位：
Fairfield University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-10-01 至 2022-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919646&HistoricalAwards=false
关键词：
MRI Acquisition Fully Motorized Research

项目摘要

An award is made to Fairfield University to fund an automated research microscope. This instrument enables projects that require detailed observations of subcellular structures, real-time imaging, and three-dimensional reconstructions of thick tissues. These sophisticated imaging techniques will be incorporated into the biology lab coursework for undergraduate science majors at Fairfield University. In addition science majors that do independent research with faculty will have access to state-of-the-art technology that both empowers their research and serves as a crucial training tool. Fairfield University has a long-standing commitment to promote science education for high school students from underserved communities through BASE Camp, a program that brings high school girls to the Fairfield University campus for summer research experiences. BASE camp students will also use this microscope in their research projects. The ability to capture detailed images of otherwise invisible subjects is awe-inspiring to students of all ages, and increases the impact of research experience on education and on attitudes toward science.A staggering breadth of research on the Fairfield campus will benefit from this instrument. It will be used to study how Candida albicans, a pathogenic fungus, constructs a biofilm and will enable researchers to visualize real-time responses to agents that disrupt biofilms. In addition it will be used to observe the subcellular localization of engineered enzymes that fluoresce upon activation. The microscope is a versatile instrument that is capable of capturing three-dimensional images of large complex organs such as the gonad in live C. elegans nematode worms. Researchers will use the C. elegans gonad to study how the regulation of microtubule motors impacts architecture of an intricate tissue. The microscope will also be used to study human cells. For example in one study users will examine how lipid raft distribution responds to dietary intervention in ex vivo peripheral blood mononuclear cells. In a different study, researchers will monitor a human cancer cell line's response to potential anti-cancer agents. These inquiries traverse the fields of genetics, development, biochemistry, metabolism, microbiology, and cancer biology, and will lead to exciting discoveries and new research trajectories.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

费尔菲尔德大学获得了一项奖励，用于资助一台自动研究显微镜。该仪器可实现需要详细观察亚细胞结构、实时成像和厚组织三维重建的项目。这些复杂的成像技术将被纳入费尔菲尔德大学科学专业本科生的生物实验室课程。此外，与教师一起进行独立研究的科学专业学生将能够获得最先进的技术，这些技术既可以增强他们的研究能力，又可以作为重要的培训工具。费尔菲尔德大学长期致力于通过 BASE Camp 促进来自服务不足社区的高中生的科学教育，该计划将高中女生带到费尔菲尔德大学校园进行夏季研究体验。 BASE 营的学生还将在他们的研究项目中使用这款显微镜。捕捉原本看不见的物体的详细图像的能力令所有年龄段的学生都惊叹不已，并增加了研究经验对教育和科学态度的影响。费尔菲尔德校园的惊人广泛的研究将受益于该仪器。它将用于研究白色念珠菌（一种病原真菌）如何构建生物膜，并使研究人员能够可视化对破坏生物膜的试剂的实时反应。此外，它将用于观察激活时发出荧光的工程酶的亚细胞定位。该显微镜是一种多功能仪器，能够捕获大型复杂器官的三维图像，例如活体线虫的性腺。研究人员将使用线虫性腺来研究微管马达的调节如何影响复杂组织的结构。该显微镜还将用于研究人体细胞。例如，在一项研究中，用户将检查脂筏分布如何响应离体外周血单核细胞的饮食干预。在另一项研究中，研究人员将监测人类癌细胞系对潜在抗癌药物的反应。这些调查横跨遗传学、发育、生物化学、新陈代谢、微生物学和癌症生物学领域，并将带来令人兴奋的发现和新的研究轨迹。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。