MRI: Acquisition of Nanoscribe Photonic Professional GT2 3D Laser Lithography System for interdisciplinary nanoscience research and training

MRI：收购 Nanoscribe Photonic Professional GT2 3D 激光光刻系统，用于跨学科纳米科学研究和培训

• 批准号: 1919653
• 负责人: Christopher Ober
• 金额: $ 39.54万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919653&HistoricalAwards=false
• 关键词: MRI; Acquisition; Nanoscribe; Photonic; Professional

Many technology advances over the last 50 years have been driven by nanofabrication techniques developed by the semiconductor industry. While powerful, they are fundamentally two dimensional technologies. In other words, they can only be used to fabricate "flat" things. The recent development of 3D printing has allowed custom manufacturing of complex three dimensional objects at millimeter resolution. Recent advances have enabled three dimensional printing/fabrication at the micrometer and nanoscale. This project enables the acquisition of a Nanoscribe Photonic Professional GT system and its deployment within the user facilities of the Cornell Nanoscale Facility (CNF). The Nanoscribe is a new type of instrument which allows three dimensional fabrication of nanoscale structures, opening many new avenues of research. One exciting development is the application of this instrument to the study of biological systems. For example, the instrument will be used to fabricate 3D structures to study cell migration in confined spaces. This project is relevant to the spread of cancer. Another project will use the Nanoscribe to fabricate "microswimmers" for targeted drug delivery applications. The instrument will be available to academic and industrial users from across the country through the well-developed CNF user program, significantly broadening its intellectual and economic impact. This instrument will have significant human resources impact in the target technical areas. The technology of the Nanoscribe is new and the skilled user base is small. Expansion of the number of users is critical to realizing its full impact. CNF will also provide new educational materials including short course lecture material and this new tool will be featured in outreach efforts.The Nanoscribe Photonic Professional GT system allows 3D nanolithography down to 160 nm using the nonlinear optical process of two photon polymerization. A near-IR laser beam, operating through a microscope objective, is scanned under computer control, with polymerization occurring only at the high photon flux focal point. CNF users will explore applications of this technology to the following major areas: (1) Micro/nanophotonics: guiding light in three dimensions and development of photonic metamaterials; (2) Nanobiotechnology: fabrication of scaffolds and micromechanical and microfluidic devices to study biochemical processes; (3) Neural electronics: Interfacing electronics with the brain and nervous system; (4) Heterointegration: Integration of electronics, photonics, and biologics through three dimensional structures. The PIs at Cornell are accomplished in the fields of Materials Science, Mechanical, and Biomedical Engineering. A number of projects will be impacted by this instrument. New polymer materials suitable for two-photon 3D printing will be developed, including elastomeric materials for nanoscale sensors and actuators. 3D nanolithography will be used to fabricate in vitro models mimicking physiological networks and interstitial spaces to study the migration of cells in confined spaces related to cancer metastasis. Fluid motile structures ("microswimmers"), that are self-actuated or remotely driven by light or ultrasound could be used in vivo to deliver drugs to targeted areas. Other principal users will use the technology to explore reactions within cells, to develop 3D scaffolds for cell growth, and for 3D photonic metamaterials. This will be a multiuser instrument with impact on a broad range of science and engineering fields. Additionally, through the CNF user program and its highly developed training process, this acquisition will have significant human resources impact in the target technical areas.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在过去的50年里，许多技术的进步都是由半导体工业开发的纳米制造技术推动的。虽然功能强大，但它们基本上是二维技术。换句话说，它们只能用来制造“扁平”的东西。最近3D打印技术的发展使得以毫米分辨率定制复杂的三维物体成为可能。最近的进展使微米和纳米级的三维打印/制造成为可能。该项目能够获得Nanoscribe光子专业GT系统，并将其部署在康奈尔纳米设施（CNF）的用户设施中。纳米书写仪是一种新型的仪器，它可以实现纳米结构的三维制造，开辟了许多新的研究途径。一个令人兴奋的发展是该仪器在生物系统研究中的应用。例如，该仪器将用于制造3D结构，以研究有限空间中的细胞迁移。这个项目与癌症的扩散有关。另一个项目将使用Nanoscribe制造用于靶向药物输送的“微游泳者”。该仪器将通过完善的CNF用户计划提供给全国各地的学术和工业用户，大大扩大其知识和经济影响。这一文书将对目标技术领域的人力资源产生重大影响。Nanoscribe的技术是新的，熟练的用户基数很小。扩大用户数量是实现其充分影响的关键。CNF还将提供新的教育材料，包括短期课程讲座材料，这个新工具将成为外展工作的特色。Nanoscribe photontonic Professional GT系统允许使用双光子聚合的非线性光学过程进行低至160纳米的3D纳米光刻。近红外激光束通过显微镜物镜，在计算机控制下进行扫描，聚合仅发生在高光子通量焦点处。CNF用户将探索该技术在以下主要领域的应用：(1)微/纳米光子学：三维引导光和光子超材料的开发；(2)纳米生物技术：用于研究生化过程的支架、微机械和微流体装置的制造；(3)神经电子学：连接大脑和神经系统的电子学；(4)异质集成：通过三维结构集成电子学、光子学和生物制品。康奈尔大学的pi是在材料科学、机械和生物医学工程领域完成的。若干项目将受到这一文书的影响。将开发适用于双光子3D打印的新型聚合物材料，包括用于纳米级传感器和执行器的弹性体材料。三维纳米光刻技术将用于制造模拟生理网络和间质空间的体外模型，以研究与癌症转移相关的细胞在密闭空间中的迁移。流体运动结构（“微游泳者”），是自我驱动的或由光或超声波远程驱动的，可在体内用于将药物输送到目标区域。其他主要用户将使用该技术探索细胞内的反应，开发用于细胞生长的3D支架，以及3D光子超材料。这将是一个多用户的仪器，对广泛的科学和工程领域产生影响。此外，通过CNF用户计划及其高度发达的培训过程，此次收购将在目标技术领域产生重大的人力资源影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。