MRI: Acquisition of Nanoscribe Photonic Professional GT2 3D Laser Lithography System for interdisciplinary nanoscience research and training

MRI：收购 Nanoscribe Photonic Professional GT2 3D 激光光刻系统，用于跨学科纳米科学研究和培训

• 批准号: 1919653
• 负责人: Christopher Ober
• 金额: $ 39.54万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919653&HistoricalAwards=false
• 关键词: MRI; Acquisition; Nanoscribe; Photonic; Professional

Many technology advances over the last 50 years have been driven by nanofabrication techniques developed by the semiconductor industry. While powerful, they are fundamentally two dimensional technologies. In other words, they can only be used to fabricate "flat" things. The recent development of 3D printing has allowed custom manufacturing of complex three dimensional objects at millimeter resolution. Recent advances have enabled three dimensional printing/fabrication at the micrometer and nanoscale. This project enables the acquisition of a Nanoscribe Photonic Professional GT system and its deployment within the user facilities of the Cornell Nanoscale Facility (CNF). The Nanoscribe is a new type of instrument which allows three dimensional fabrication of nanoscale structures, opening many new avenues of research. One exciting development is the application of this instrument to the study of biological systems. For example, the instrument will be used to fabricate 3D structures to study cell migration in confined spaces. This project is relevant to the spread of cancer. Another project will use the Nanoscribe to fabricate "microswimmers" for targeted drug delivery applications. The instrument will be available to academic and industrial users from across the country through the well-developed CNF user program, significantly broadening its intellectual and economic impact. This instrument will have significant human resources impact in the target technical areas. The technology of the Nanoscribe is new and the skilled user base is small. Expansion of the number of users is critical to realizing its full impact. CNF will also provide new educational materials including short course lecture material and this new tool will be featured in outreach efforts.The Nanoscribe Photonic Professional GT system allows 3D nanolithography down to 160 nm using the nonlinear optical process of two photon polymerization. A near-IR laser beam, operating through a microscope objective, is scanned under computer control, with polymerization occurring only at the high photon flux focal point. CNF users will explore applications of this technology to the following major areas: (1) Micro/nanophotonics: guiding light in three dimensions and development of photonic metamaterials; (2) Nanobiotechnology: fabrication of scaffolds and micromechanical and microfluidic devices to study biochemical processes; (3) Neural electronics: Interfacing electronics with the brain and nervous system; (4) Heterointegration: Integration of electronics, photonics, and biologics through three dimensional structures. The PIs at Cornell are accomplished in the fields of Materials Science, Mechanical, and Biomedical Engineering. A number of projects will be impacted by this instrument. New polymer materials suitable for two-photon 3D printing will be developed, including elastomeric materials for nanoscale sensors and actuators. 3D nanolithography will be used to fabricate in vitro models mimicking physiological networks and interstitial spaces to study the migration of cells in confined spaces related to cancer metastasis. Fluid motile structures ("microswimmers"), that are self-actuated or remotely driven by light or ultrasound could be used in vivo to deliver drugs to targeted areas. Other principal users will use the technology to explore reactions within cells, to develop 3D scaffolds for cell growth, and for 3D photonic metamaterials. This will be a multiuser instrument with impact on a broad range of science and engineering fields. Additionally, through the CNF user program and its highly developed training process, this acquisition will have significant human resources impact in the target technical areas.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在过去的50年中，许多技术的进步都是由半导体行业开发的纳米制作技术驱动的。虽然强大，但从根本上讲，它们是二维技术。换句话说，它们只能用于制造“平坦”的东西。 3D打印的最新开发允许以毫米分辨率定制复杂的三维对象。最近的进步使千分尺和纳米级的三维印刷/制造能够。该项目使得在康奈尔纳米级设施（CNF）的用户设施中获得了Nanoscribe光子专业GT系统及其部署。 Nanoscribe是一种新型的仪器，允许三维制造纳米级结构，开辟了许多新的研究途径。一个令人兴奋的发展是该工具在生物系统研究中的应用。例如，该仪器将用于制造3D结构以研究狭窄空间中的细胞迁移。该项目与癌症的传播有关。另一个项目将使用Nanoscribe来制造针对有针对性药物的“微武器”。该工具将通过发达的CNF用户计划向全国各地的学术和工业用户提供，从而大大扩大其智力和经济影响。该工具将在目标技术领域具有重大的人力资源影响。 Nanoscribe的技术是新的，熟练的用户群很小。扩大用户数量对于实现其全部影响至关重要。 CNF还将提供新的教育材料，包括短期课程材料，该新工具将在外展工作中进行特征。Nanoscribe光子专业GT系统允许使用两个光子聚合的非线性光学过程，将3D纳米光刻降低至160 nm。通过显微镜物镜运行的近红外激光束在计算机控制下进行扫描，聚合仅发生在高光子通量焦点处。 CNF用户将探索该技术在以下主要领域的应用：（1）微/纳米光子学：指导光在三个维度和光子超材料的开发中； （2）纳米生物技术：脚手架以及微力和微流体设备的制造，以研究生化过程； （3）神经电子：将电子与大脑和神经系统接口； （4）杂积：通过三维结构通过三维结构整合电子，光子学和生物制剂。康奈尔（Cornell）的PI在材料科学，机械和生物医学工程领域完成。该工具将受到许多项目的影响。将开发适用于两光子3D打印的新聚合物材料，包括用于纳米级传感器和执行器的弹性材料。 3D纳米光刻将用于制造模仿生理网络和间质空间的体外模型，以研究与癌症转移相关的密闭空间中细胞的迁移。可以在体内使用自动驱动或远程驱动的流体运动结构（“微晶状体”），它们可以在体内使用光或超声驱动。其他主要用户将使用该技术探索细胞内的反应，为细胞生长开发3D支架以及3D光子超材料。这将是一种多用途仪器，对广泛的科学和工程领域有影响。此外，通过CNF用户计划及其高度开发的培训过程，此次收购将对目标技术领域产生重大的人力资源影响。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛影响的评估评估评估的评估来支持的。