MRI: Acquisition of a 7T magnetic resonance system for high resolution imaging of brain connectivity and dynamics

MRI：获取 7T 磁共振系统，用于大脑连接和动力学的高分辨率成像

• 批准号: 1920364
• 负责人: Mikhail Shapiro
• 金额: $ 100万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1920364&HistoricalAwards=false
• 关键词: MRI; Acquisition; 7T; magnetic; resonance

An award is made to the California Institute of Technology to purchase state-of-the-art equipment for a 7-Tesla magnetic resonance imaging (MRI) instrument for brain imaging. This instrument will enable cutting-edge basic research, as well as research-intensive training, at the Caltech Brain Imaging Center (CBIC) aimed at investigating brain structure and function in a range of animal species. The research will engage more than a dozen different labs at Caltech pursuing basic scientific questions, including a large number of postdoctoral fellows, graduate students, undergraduates and high school summer students. Special emphasis will be placed on increasing the representation of women and underrepresented minority students in education and research. This includes Caltech's Ph.D. programs as well as its Summer Undergraduate Research Fellows program and WAVE program, which welcome students from outside Caltech and focus on increasing the participation of underrepresented students in science, technology, engineering and math. It also includes the Caltech Classroom Connection, a science education outreach program partnering Caltech scientists with K-12 teachers in the local public school system to provide summer research experiences for K-12 students. Additional educational impact will come from the use of this instrument in connection with courses. In addition, the MRI instrument will be made available to academic institutions in the Greater Los Angeles area. The insights into the structure and function of the brain obtained through this research and communicated through public outreach will contribute broadly to scientific literacy. The specific goals of the supported research are to elucidate fundamental principles of brain structure, function and dysfunction; to test, develop, and compare synergistic technologies for investigating the brain; and to train the next generation of students and scientists in this endeavor. Specific aims will investigate the structural and functional connectivity of the brain, knowledge that is essential for formulating and testing computational models of brain function and allowing comparisons among species. Convergent technologies will also be used to investigate the brain, including the use of functional MRI, ultrasound and photoacoustic tomography. The research will develop the next generation of genetically encoded molecular probes for MRI, and will enable more precise imaging and manipulation of biological function at the cellular and circuit level. This research will leverage unique connections to studies conducted on Caltech's human MRI scanners, enabling novel advances in the study of brain structure and function across species. Results from the research will be disseminated in peer-reviewed publications and at scientific meetings.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

加州理工学院被授予购买最先进的设备，用于脑成像的7特斯拉磁共振成像(MRI)仪器。该仪器将在加州理工大学脑成像中心(CBIC)进行尖端基础研究以及研究密集型培训，旨在研究一系列动物物种的大脑结构和功能。这项研究将涉及加州理工大学十几个不同的实验室，研究基本的科学问题，包括大量的博士后研究员、研究生、本科生和高中暑期学生。将特别强调增加妇女和代表不足的少数族裔学生在教育和研究中的代表性。这包括加州理工学院的博士项目以及暑期本科生研究员项目和WAVE项目，这些项目欢迎来自加州理工学院以外的学生，并专注于增加未被充分代表的学生在科学、技术、工程和数学领域的参与。它还包括加州理工学院课堂连接，这是一个科学教育推广计划，加州理工学院的科学家与当地公立学校系统的K-12教师合作，为K-12学生提供暑期研究体验。在课程中使用这一工具将产生额外的教育影响。此外，核磁共振仪器将向大洛杉矶地区的学术机构提供。通过这项研究获得并通过公众宣传传播的对大脑结构和功能的见解将广泛有助于科学素养。受资助研究的具体目标是阐明大脑结构、功能和功能障碍的基本原理；测试、开发和比较研究大脑的协同技术；以及培训下一代学生和科学家进行这方面的努力。具体目标将研究大脑的结构和功能连接，这是形成和测试大脑功能计算模型并允许进行物种间比较所必需的知识。融合技术还将用于研究大脑，包括使用功能磁共振成像、超声波和光声断层扫描。这项研究将为核磁共振开发下一代遗传编码的分子探针，并将在细胞和电路水平上实现更精确的生物功能成像和操作。这项研究将利用与加州理工大学人类核磁共振扫描仪进行的研究的独特联系，使跨物种的大脑结构和功能研究取得新的进展。这项研究的结果将在同行评议的出版物和科学会议上传播。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。