Doctoral Dissertation Research: Aging, frailty, and foraging ability in wild male primates
博士论文研究:野生雄性灵长类动物的衰老、衰弱和觅食能力
基本信息
- 批准号:1927384
- 负责人:
- 金额:$ 1.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
While longevity is often described as a uniquely human trait, other apes like chimpanzees also have extended lifespans, living twice as long as monkeys or lemurs. However, we don't fully understand the effects of aging on apes in the wild or which aspects of human longevity are unique. This doctoral research project will investigate how wild male chimpanzees age physiologically and behaviorally with a focus on how aging impacts foraging ability, which may reveal how frailty impacts fitness. The findings will help clarify whether chimpanzees' feeding behavior and performance change with age, and whether foraging could play an important role in shaping their patterns of senescence. This research will fill gaps in our knowledge on the senescence of male primate skeletal biology and may help to clarify whether fertility maintained late in life contributes to the evolution of extended lifespan. The investigators will engage in educational activities in the United States and near the research site in rural Uganda, and foster international research collaborations and capacity building. In addition, the continued presence of researchers in Kibale National Park helps protect one of the last tropical rainforests in all of East Africa, which is notably one of the principal strongholds of chimpanzees in this area.The proposed research will investigate aging in male chimpanzees living in an exceptionally large community at Ngogo, Kibale National Park, Uganda. The investigators will assess the physiological traits of adult male chimpanzees at various ages to assess how bone density, body mass, chewing ability, and energetic status may decrease in old age. To this end, the research will non-invasively collect and analyze fecal samples to assess chewing efficiency as well as urine samples to measure insulin biomarkers (an indicator of energetic status) and collagen biomarkers to investigate decreases in bone density. Behavioral observations will also be carried out to assess how these physical changes may impact movement, food selection, ingestion rates, mating effort, and sociality. Through a systematic study of aging male chimpanzees' physiology and behavior, this research aims to elucidate the processes of aging and its impact on fitness in wild animals.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
虽然长寿通常被描述为人类独有的特征,但黑猩猩等其他类人猿的寿命也更长,寿命是猴子或狐猴的两倍。然而,我们并不完全了解在野外衰老对猿类的影响,也不完全了解人类长寿的哪些方面是独一无二的。这个博士研究项目将调查野生雄性黑猩猩如何在生理和行为上变老,重点是衰老如何影响觅食能力,这可能揭示虚弱如何影响健康。这些发现将有助于澄清黑猩猩的进食行为和表现是否会随着年龄的变化而变化,以及觅食是否会在塑造它们的衰老模式方面发挥重要作用。这项研究将填补我们在男性灵长类骨骼生物学衰老方面的知识空白,并可能有助于澄清晚年保持的生育能力是否有助于延长寿命的进化。研究人员将在美国和乌干达农村地区的研究地点附近从事教育活动,并促进国际研究合作和能力建设。此外,基巴莱国家公园研究人员的持续存在有助于保护整个东非最后的热带雨林之一,这是该地区黑猩猩的主要据点之一。拟议中的研究将调查生活在乌干达基巴莱国家公园恩戈戈一个特别大的社区中的雄性黑猩猩的衰老情况。研究人员将评估不同年龄的成年雄性黑猩猩的生理特征,以评估骨密度、身体质量、咀嚼能力和精力状态在老年时可能会如何下降。为此,这项研究将非侵入性地收集和分析粪便样本以评估咀嚼效率,以及尿样以测量胰岛素生物标记物(能量状态的指示器)和胶原生物标记物以调查骨密度的下降。还将进行行为观察,以评估这些身体变化如何影响运动、食物选择、摄取率、交配努力和社交。通过对雄性黑猩猩衰老生理和行为的系统研究,这项研究旨在阐明野生动物衰老的过程及其对健康的影响。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrew Marshall其他文献
A Low-Power Multi-Gate FET CMOS Technology with 13.9ps Inverter Delay, Large-Scale Integrated High Performance Digital Circuits and SRAM
具有 13.9ps 逆变器延迟、大规模集成高性能数字电路和 SRAM 的低功耗多栅极 FET CMOS 技术
- DOI:
10.1109/vlsit.2007.4339745 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
K. Arnim;Emmanuel Augendre;A. C. Pacha;Thomas G. Schulz;K. T. San;Friedrich L. Bauer;A. Nackaerts;R. Rooyackers;T. Vandeweyer;B. Degroote;N. Collaert;A. Dixit;Raghunath Singanamalla;Wade Xiong;Andrew Marshall;C. Cleavelin;K. Schrüfer;Malgorzata Jurczak - 通讯作者:
Malgorzata Jurczak
HGS launches “first” genomics product in clinic
HGS 在临床中推出“首个”基因组学产品
- DOI:
10.1038/nbt0298-129 - 发表时间:
1998-02-01 - 期刊:
- 影响因子:41.700
- 作者:
Andrew Marshall - 通讯作者:
Andrew Marshall
Autonomous Development of a Machine-Learning Model for the Plastic Response of Two-Phase Composites from Micromechanical Finite Element Models
根据微机械有限元模型自主开发两相复合材料塑性响应的机器学习模型
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:2.6
- 作者:
Andrew Marshall;S. Kalidindi - 通讯作者:
S. Kalidindi
Scientific Committee
科学委员会
- DOI:
10.1111/hdi.12354 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Professor Meryem Duygun;FAcSS;Jos é ;Raffaele Santioni;Matteo D'Amato;Massimiliano Affinito;Bernardus Van Doornik;David Schoenherr;J. Skrastins;Eghbal Rahimikia;Stefan Zohren;S. Poon;George Jiang;Huacheng Zhang;Hryckiewicz Aneta;Tchorzewska Kinga;Borsuk Marcin;Dimitris Tsomocos;Leon Anidjar;Nizan Geslevich Packin;Argyri Panezi;Ganesh Viswanath;Pietro Saggese;Esther Segalla;Michael Sigmund;B. Raunig;Felix Zangerl;Bernhard Haselhofer;Nico Lauridsen;Barry Eichengreen;My Nguyen;A. Bernales;Deniz Aydin;Roberta Adami;Issam Malki;Dildora Ibragimova;Sheeja Sivaprasad;Feruza Yodgorova;Jozef Baruník;Carlos Cañón;Eddie Gerba;Z. Sautner;Jing Yu;Rui Zhong;Xiaoyan Zhou;Tianshu Zhao;A. Garang;V. Songwe;Christoffer Kok;Yener Altunbaş;Giuseppe Avignone;Cosimo Pancaro;Mikel Bedayo;Jorge Galán;Vikram Nanda;Winifred Huang;Ahmet Karpuz;Neslihan Ozkan;Md Al Mamun;Balasingham Balachandran;H. N. Duong;Md Imran Hossain;Zhonghao Jiang;Yukun Shi;Lu Xing;Suman Banerjee;M. Humphery‐Jenner;Xingjian Zhang;Beatrice Bertelli;Muhammad Usman Khurram;Xuewu Wang;Renxuan Wang;Cheng Jiang;Zhipeng Yan;Muhammad Farooq;Saqib Aziz;Yannick Michiels;D. Nguyen;C. Torricelli;Mouctar Bah;Koen Inghelbrecht;Koen Schoors;Nicolas Soenen;R. V. Vennet;Michela Altieri;Deyan Radev;M. Bardoscia;F. Caccioli;Haotian Gao;Anil Jain;Leonidas Barbopoulos;Anthony Saunders;Nadia Massoud;Xiao Chen;Maggie Hu;Bohui Zhang;E. Kalotychou;Lefteris Andreadis;C. Louca;Christian Lundblad;Christos Makrides;Dimitrios Gounopoulos;Anh Do;David Newton;Tam Nguyen;Nazanin Babolmorad;Peter Bossaerts;Min Dai;Steven Kou;Shuaijie Qian;Ling Qin;Helen Popper;David Parsley;Dongna Zhang;Xingyu Dai;Qunwei Wang;Marco Chi;Keung Lau;Xiuping Hua;Jiadong Peng;S. Cheng;Jianwei Hu;S. Boccaletti;Annalisa Ferrando;Emanuele Rossi;Monica Rossolini;Manish Gupta;S. Ongena;Tianxi Wang;Xuan Wang;Ahmed Barakat;Maurizio Fiaschetti;Tian Han;Enrico Onali;Afshin Sabri;M. Tsionas;Huamao Wang;N. Michelson;Cecilia Dassatti;F. R. Tous;Rodrigo Lluberas;Santiago Barraza;Andrea Civelli;David Marqués;Horacio Sapriza;Alex Sclip;Marta Degl'Innocenti;Michael Bowe;O. Kolokolova;Lijie Yu;Ania Zalewska;Yue Zhang;Zhe Zong;H. Farag;Andrew Marshall;Biwesh Neupane;Santosh Koirala;Taufiq Choudhry;Si Zhou;Yue Zhou;Pejman Abedifar;Jair N. Ojeda;Sergi Basco;George Kladakis;Alexandros Skouralis;Gazi Kara;David Arseneau;S. Kashizadeh;Yavuz Arslan;Bulent Guler;B. Kurusçu;Johannes Jacob Fischer;Natalie Kessler;Ken Deng;Joel Shapiro;Jens Christensen;Sarah Mouabbi;P. Coen;Esther Caceres Garcia;Matias Lamas Rodriguez;Daniel Batista da Silva;Marcelo Fernandes;Martin Hodula;Milan Szabo;Josef Bajzík;Stuart Hyde;M. Filippidis;Ioannis Chatziantoniou;G. Filis;Panagiotis Tzouvanas;Gonul Colak;Kai Yao;Thanaset Chevapatrakul;Shiyan Yin;Thach Nguyen;Francisco Pinto;Chaoyan Wang;Luboš Hanus;Lukáš Vácha;S. Rudkin;Wanling Rudkin;Paweł Dłotko;Kuntara Pukthuanthong;Zhihua Wei;Aoran Zhang;Yunfei Zhao;Fuwei Jiang;Zhuoshi Liu;A. Pozzolo;Andrés Raúl;Cruz Hernández;Andrés Mora;Michael Brei;Oskar Kowalewski;P. Śpiewanowski;Eric Strobl;Carlo Chiarella;P. Cuadros;Ludovico Rossi - 通讯作者:
Ludovico Rossi
164 - Exploring the optimal diagnostic threshold value of corneal nerve fibre length (CNFL) for diabetic neuropathy (DN) identification
- DOI:
10.1016/j.jcjd.2017.08.172 - 发表时间:
2017-10-01 - 期刊:
- 影响因子:
- 作者:
Leif E. Lovblom;Vera Bril;Andrej Orszag;Katie Edwards;Nicola Pritchard;Anthony Russel;Daniel Pacaud;Kenneth Romanchuk;Jean Mah;Maria Jeziorska;Andrew Marshall;Roni M. Shtein;Rodica Pop-Busui;Eva L. Feldman;Andrew JM Boulton - 通讯作者:
Andrew JM Boulton
Andrew Marshall的其他文献
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{{ truncateString('Andrew Marshall', 18)}}的其他基金
Doctoral Dissertation Research: Gut microbiome and response to environmental change
博士论文研究:肠道微生物组和对环境变化的反应
- 批准号:
2236061 - 财政年份:2023
- 资助金额:
$ 1.78万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Ecological influences on coming to the ground in tree-dwelling primates
博士论文研究:树栖灵长类动物落地的生态影响
- 批准号:
2216525 - 财政年份:2022
- 资助金额:
$ 1.78万 - 项目类别:
Standard Grant
Novel Mid IR single Photon Detectors for Quantum Systems
用于量子系统的新型中红外单光子探测器
- 批准号:
EP/M508299/1 - 财政年份:2015
- 资助金额:
$ 1.78万 - 项目类别:
Research Grant
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