New polymerisation processes for the synthesis of novel biopolymers

用于合成新型生物聚合物的新聚合工艺

• 批准号: DP0877914
• 负责人: Prof Andrea Robinson
• 金额: $ 15.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-02 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877914
• 关键词: New; polymerisation; processes; synthesis; novel

Synthetic peptide-based vaccines, formed via polymerisation of small bioactive motifs, possess several advantages over traditional approaches and promise to be the multi-disease targeting vaccines of the future. Disease targets will include influenza and hepatitis C viruses and a toxin from enteropathogenic Escherichia coli. These three diseases are in desperate need of novel vaccine approaches and the chemistries described in this proposal represent a conceptual leap over traditional, and so far ineffective approaches investigated thus far. Synthetic antifreeze proteins and bioelastomers will also be constructed using our catalysis driven polymerisation process and applied to unmet medical and industrial needs.

合成多肽疫苗是通过聚合小的生物活性基序形成的，与传统方法相比具有几个优点，有望成为未来的多疾病靶向疫苗。疾病目标将包括流感和丙型肝炎病毒以及一种来自肠道致病性大肠杆菌的毒素。这三种疾病迫切需要新的疫苗方法，本提案中描述的化学方法代表着对迄今为止研究的传统和无效方法的概念飞跃。合成抗冻蛋白和生物弹性体也将使用我们的催化驱动聚合工艺来构建，并应用于未得到满足的医疗和工业需求。