New methods for the synthesis of stable cyclic peptides

稳定环肽合成新方法

• 批准号: DP0772124
• 负责人: Prof Andrea Robinson
• 金额: $ 19.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-02 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0772124
• 关键词: New; methods; synthesis; stable; cyclic

This proposal will design, synthesise and evaluate novel carbocyclic analogues of cyclic peptides which have application in the treatment of pain, diabetes management, malaria, and cancer therapy and diagnosis. The carbocyclic analogues will have improved biostability and will also provide the opportunity for oral administration. Carbacyclic analogues of insulin could lead to improved treatment of Australia's 1.2 million diabetics including many Aboriginal Australians who are particularly susceptible to Type II diabetes and its debilitating complications.

这项建议将设计、合成和评估新的环肽碳环类似物，这些环肽在治疗疼痛、糖尿病治疗、疟疾和癌症治疗和诊断中具有应用价值。碳环类似物将具有更好的生物稳定性，也将提供口服给药的机会。胰岛素的碳环类似物可以改善澳大利亚120万糖尿病患者的治疗，其中包括许多特别容易患II型糖尿病及其令人衰弱的并发症的土著澳大利亚人。