Enhancement of monopartite geminivirus pathogenicity by satellite DNA beta encoded betaC1 protein: the role of host factors

卫星DNAβ编码的βC1蛋白增强单联双生病毒的致病性：宿主因素的作用

• 批准号: DP0881545
• 负责人: Prof John Randles
• 金额: $ 11.68万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0881545
• 关键词: Enhancement; monopartite; geminivirus; pathogenicity; satellite

Australian incursions of geminiviruses are uncontrollable due to their unique mode of spread by whiteflies. The first incursion in Darwin in 1970 has spread to Far Northern Queensland. The second in SE Queensland in 2006 is estimated to cause $500 million loss to horticulture. Our $2 billion cotton industry is threatened by cotton leaf curl diseases from South Asia, where DNA beta enhances virus replication and disease severity. DNA beta has the potential to enter Australia with several different geminiviruses and to spread into others by co-infection, which requires research on detection and pathogenesis of DNA beta.

澳大利亚的双生病毒入侵是无法控制的，因为它们独特的传播模式是由粉虱传播的。1970年在达尔文的第一次入侵已经蔓延到远北方昆士兰州。2006年在东南部昆士兰州发生的第二次地震估计给园艺业造成5亿美元的损失。我们价值20亿美元的棉花产业受到来自南亚的棉花曲叶病的威胁，在那里，DNA β增强了病毒复制和疾病的严重性。 DNA β有可能与几种不同的双生病毒一起进入澳大利亚，并通过合并感染传播到其他国家，这需要对DNA β的检测和发病机制进行研究。