STTR Phase I: Ambulatory, Beat-to-Beat Blood Pressure Tracking Enabled by Wireless, Tri-Mode Electronic Tattoos

STTR 第一阶段：通过无线三模式电子纹身实现动态逐搏血压追踪

• 批准号: 1938254
• 负责人: Pulin Wang
• 金额: $ 22.49万
• 依托单位: Stretch Med, inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1938254&HistoricalAwards=false
• 关键词: STTR; Phase; Ambulatory; Beat; Blood

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is to address hypertension, which affects about 75 million Americans and is the primary or contributing cause of nearly 500,000 deaths every year in the U.S. A high-fidelity and high wearability blood pressure (BP) tracker will help the diagnosis and control of hypertension. The proposed project Advance the design and manufacture of wear-and-forget e-tattoos, a stretchable hybrid electronic device integrating both rigid and soft components on a tattoo-like platform, serving as a model for future soft wearable electronics. In addition to the societal impact of improving the lives of hypertension patients, noninvasive imperceptible real-time BP monitoring would assist many fields related to human health and performance, such as fitness training, sleep studies, and clinical trials for prospective therapeutic treatments. The proposed STTR Phase I project will develop an electro-mechanical-acoustic cardiac (EMAC) tattoo for continuous and beat-to-beat blood pressure (BP) tracking. The project will develop: 1) A combined hardware and software strategy for motion artifact minimization, long sought for any ambulatory biometrics sensing; and 2) A machine learning algorithm for personalized recognition and warning of abnormal BP events; 3) An integrated systems solution. These innovations together enable the first ambulatory, beat-to-beat ambulatory BP tracking system with high wearability, low motion artifacts, and warning capabilities in an e-tattoo wearable format.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业技术转让（STTR）第一阶段项目的更广泛影响是解决高血压问题，高血压影响着约7500万美国人，是美国每年近50万人死亡的主要原因或促成原因。拟议项目推进穿戴式电子纹身的设计和制造，这是一种可伸缩的混合电子设备，在类似纹身的平台上集成了刚性和柔性组件，作为未来软可穿戴电子产品的模型。除了改善高血压患者生活的社会影响外，无创性不易察觉的实时BP监测还将有助于与人类健康和表现相关的许多领域，例如健身训练，睡眠研究和前瞻性治疗的临床试验。拟议的STTR第一阶段项目将开发一种机电声心脏（EMAC）纹身，用于连续和逐搏血压（BP）跟踪。 该项目将开发：1）运动伪影最小化的组合硬件和软件策略，长期以来一直寻求任何动态生物识别传感;和2）用于个性化识别和异常BP事件警告的机器学习算法; 3）集成系统解决方案。这些创新共同实现了第一个具有高可穿戴性、低运动伪影和电子纹身可穿戴格式警告功能的动态、逐搏动态BP跟踪系统。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。