SBIR Phase I: Broad Spectrum biorational bio- and synthetic insecticides and mosquito repellents

SBIR 第一阶段：广谱生物合理的生物和合成杀虫剂和驱蚊剂

• 批准号: 1938569
• 负责人: Nadia Adam
• 金额: $ 22.5万
• 依托单位: Biomineral Systems LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2021-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1938569&HistoricalAwards=false
• 关键词: SBIR; Phase; Broad; Spectrum; biorational

The broader impact/commercial potential of this SBIR project proposing a novel broad spectrum insecticide safe for humans, expected to be safer than synthetic insecticides. It will be used in conventional and organic farming, as well as personal protection/mosquito repellent products, costing significantly less than the products currently on the market. Crop losses due to insect pests cost billions of dollars and the limited classes of insecticides are vulnerable to the constant threat of resistance. In addition, the lack of specificity creates broad risks due to pesticide residues polluting food and water and causing environmental damage. In particular, organic farming needs effective bioinsecticides for economically sustainable yields. The proposed product will have applications to other mosquito-borne diseases without adverse effects on human health.This SBIR Phase I project proposes to combine an effective insect protein target with a new class of molecules. In particular, a single molecule and its analogs derived from easily produced and cheaply priced natural products create new options for cost-effective and scalable de-novo synthesis for mass production. A few separate molecules from this general class have been shown to possess the right mechanism of insecticidal activity specific to insects (not humans). The specific protein target has a well conserved active site across arthropods (insects). Preliminary technical feasibility has been established and the Phase I work plan will validate proof-of-concept for the proposed solution.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个SBIR项目的更广泛的影响/商业潜力提出了一种对人类安全的新型广谱杀虫剂，预计将比合成杀虫剂更安全。它将用于传统和有机农业，以及个人防护/驱蚊产品，成本大大低于目前市场上的产品。虫害造成的农作物损失高达数十亿美元，有限种类的杀虫剂很容易受到持续不断的抗药性威胁。此外，缺乏特异性造成了广泛的风险，因为农药残留污染了食品和水，并造成了环境破坏。特别是，有机农业需要有效的生物杀虫剂才能获得经济上可持续的产量。建议的产品将应用于其他蚊媒疾病，而不会对人类健康产生不利影响。这项SBIR第一阶段项目建议将有效的昆虫蛋白质靶标与一类新的分子结合。特别是，从容易生产和廉价的天然产品中提取的单一分子及其类似物为大规模生产提供了具有成本效益和可扩展的从头合成的新选择。这一类中的几个独立分子已被证明具有对昆虫(而不是人类)特有的杀虫活性的正确机制。特定的蛋白质靶标在节肢动物(昆虫)中有一个保守的活性部位。初步的技术可行性已经确定，第一阶段工作计划将验证拟议解决方案的概念验证。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。