SBIR Phase I: An Ingestible Intraluminal Bioelectronic Capsule (IBC) for Closed-Loop Diagnosis and Treatment of Gastrointestinal Disorders

这个小型企业创新研究（SBIR）第一阶段项目的更广泛影响集中在多模式胃肠道测量，用于快速检测和治疗手术后并发症。美国每年有超过30万名患者接受腹部切除手术。这些患者通常会出现严重的并发症，如术后肠梗阻、胃肠道出血和吻合口瘘，这些严重影响生活质量。治疗并发症会延长住院时间，每天花费2 000美元;仅术后肠梗阻一项，每年因住院时间延长而增加的费用就超过15亿美元。快速检测和治疗这些并发症可以加速康复，实现闭环治疗，并提高生活质量。该小型企业创新研究（SBIR）第一阶段项目将开发用于检测手术后并发症的新传感模式，将它们组合成可用于体内科学研究的单个小型胶囊，并使用猪模型测试该设备。该项目的重点是开发多模态传感技术，以非侵入性地诊断这些并发症。 该项目目标的完成将为术后胃肠道并发症的遥测闭环治疗铺平道路。此外，在这项工作中收集的数据和开发的工具将为未来的研究提供信息，使用猪模型的胃肠道扰动和recovery.This奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project focuses on multi-modal gastrointestinal measurements for rapid detection and treatment of post-surgical complications. Over 300,000 patients in the US undergo abdominal resection surgery each year. These patients often experience serious complications, such as post-operative ileus, gastrointestinal hemorrhage, and anastomotic leakage, that significantly impact quality of life. Treating complications extends hospitalization time at a rate of $2,000 per day; for post-operative ileus alone, additional costs due to prolonged hospitalization time exceed $1.5 billion annually. Rapid detection and treatment of these complications could accelerate recovery, enable closed-loop therapies, and increase quality of life. This Small Business Innovation Research (SBIR) Phase I project will develop new sensing modalities for detecting post-surgical complications, combining them into a single miniaturized capsule which can be used for in vivo scientific research studies, and testing this device using a porcine model. This project focuses on developing multi-modal sensing technologies to non-invasively diagnose these complications. Completion of the aims of this project will pave the way towards telemetric, closed-loop therapies for post-operative gastrointestinal complications. In addition, data gathered and tools developed during this effort will inform future studies using a porcine model of gastrointestinal perturbation and recovery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.