SBIR Phase I: An Ingestible Intraluminal Bioelectronic Capsule (IBC) for Closed-Loop Diagnosis and Treatment of Gastrointestinal Disorders

这项小企业创新研究（SBIR）第一阶段项目的广泛影响侧重于多模式胃肠道测量，以快速检测和治疗手术后并发症。在美国，每年有超过30万患者接受腹部切除手术。这些患者经常出现严重的并发症，如术后肠梗阻、胃肠道出血和吻合口瘘，严重影响生活质量。治疗并发症延长住院时间，每天费用为2 000美元；仅术后肠梗阻一项，因住院时间延长而造成的额外费用每年超过15亿美元。快速发现和治疗这些并发症可以加速康复，实现闭环治疗，并提高生活质量。这个小企业创新研究（SBIR）第一阶段项目将开发新的传感模式，用于检测手术后并发症，将它们结合到一个小型胶囊中，可用于体内科学研究，并使用猪模型测试该设备。本项目的重点是开发多模态传感技术，以非侵入性地诊断这些并发症。该项目的完成将为术后胃肠道并发症的遥测、闭环治疗铺平道路。此外，在此过程中收集的数据和开发的工具将为使用猪胃肠道紊乱和恢复模型的未来研究提供信息。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project focuses on multi-modal gastrointestinal measurements for rapid detection and treatment of post-surgical complications. Over 300,000 patients in the US undergo abdominal resection surgery each year. These patients often experience serious complications, such as post-operative ileus, gastrointestinal hemorrhage, and anastomotic leakage, that significantly impact quality of life. Treating complications extends hospitalization time at a rate of $2,000 per day; for post-operative ileus alone, additional costs due to prolonged hospitalization time exceed $1.5 billion annually. Rapid detection and treatment of these complications could accelerate recovery, enable closed-loop therapies, and increase quality of life. This Small Business Innovation Research (SBIR) Phase I project will develop new sensing modalities for detecting post-surgical complications, combining them into a single miniaturized capsule which can be used for in vivo scientific research studies, and testing this device using a porcine model. This project focuses on developing multi-modal sensing technologies to non-invasively diagnose these complications. Completion of the aims of this project will pave the way towards telemetric, closed-loop therapies for post-operative gastrointestinal complications. In addition, data gathered and tools developed during this effort will inform future studies using a porcine model of gastrointestinal perturbation and recovery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.