OPUS: CRS: Comparative life history of microbes

OPUS：CRS：微生物的比较生活史

• 批准号: 1939423
• 负责人: Steven Frank
• 金额: $ 25.39万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1939423&HistoricalAwards=false
• 关键词: OPUS; CRS; Comparative; life; history

This project studies the characteristics of bacteria and other microbes, such as yeast. In recent years, scientists have made great advances in describing how microbes grow on different kinds of food and how they compete with each other. Scientists have also described the many ways in which microbes affect the health of humans and other organisms. However, scientists understand much less about why different microbes have come to be so different in the ways in which they feed, compete with each other, and influence the health of other organisms. The goal of this project is to study the processes in nature that have shaped microbial characteristics. Such understanding from the new research will lead to specific predictions about how microbes are expected to differ when in habitats that have not previously been studied. Those predictions can be tested by the many microbiologists working on these problems, leading to better scientific insight, to more efficient response to challenges, and to improved management of resources. The new work will also provide insight into how human activities will likely alter the biology of these microbial organisms that so strongly affect the environment and the health of ecosystems.This project will synthesize the investigator’s past theoretical work on fitness and past applications to microbes with the novel challenges posed by recent empirical advances. The project will deliver a series of synthesis articles on microbial life history. Each article will unify the conceptual framework for fitness and evolutionary process with the specific empirical challenges for microbial traits. Individual articles will focus on topics such as metabolism, siderophores, quorum sensing, cross feeding, and exodigestion. The comparative predictions of this synthesis will motivate the next generation of empirical studies to advance the topic beyond its current limitations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个项目研究细菌和其他微生物的特征，如酵母。近年来，科学家在描述微生物如何在不同种类的食物上生长以及它们如何相互竞争方面取得了很大进展。科学家们还描述了微生物影响人类和其他生物体健康的许多方式。然而，科学家们对为什么不同的微生物在取食、相互竞争和影响其他微生物的健康方面会有如此大的差异，了解得要少得多。这个项目的目标是研究自然界中塑造微生物特征的过程。这项新研究的这种理解将导致对微生物在以前没有被研究的栖息地中的预期差异的具体预测。这些预测可以被致力于这些问题的许多微生物学家检验，从而获得更好的科学洞察力，更有效地应对挑战，并改善资源管理。这项新的工作还将提供对人类活动可能如何改变这些微生物的生物学的洞察，这些微生物对环境和生态系统的健康有如此强烈的影响。这个项目将把研究人员过去关于适宜性的理论工作和过去对微生物的应用与最近的经验进展提出的新挑战相结合。该项目将发表一系列关于微生物生命史的综合文章。每一篇文章都将统一适合度和进化过程的概念框架，以及微生物特征的具体经验挑战。个别文章将集中于新陈代谢、铁载体、群体感应、交叉喂养和体外消化等主题。这一综合的比较预测将激励下一代实证研究超越其目前的限制。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Robustness increases heritability: implications for familial disease

稳健性增加遗传力：对家族性疾病的影响

• DOI: 10.1093/evolut/qpac026
• 发表时间: 2023
• 期刊: Evolution
• 影响因子: 3.3
• 作者: Frank, Steven A.

Metabolic Heat in Microbial Conflict and Cooperation

• DOI: 10.3389/fevo.2020.00275
• 发表时间: 2020-05
• 作者: S. Frank

Numbers of Mutations within Multicellular Bodies: Why It Matters

• DOI: 10.3390/axioms12010012
• 发表时间: 2023-01-01
• 期刊: AXIOMS
• 影响因子: 2
• 作者: Frank，Steven A.

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal

一种增强的转录因子抑制因子，可缓冲随机性并产生不稳定的外部昼夜节律信号

• DOI: 10.3389/fsysb.2023.1276734
• 发表时间: 2023
• 期刊: Frontiers in Systems Biology
• 作者: Frank, Steven A.

Robustness and complexity

稳健性和复杂性

• DOI: 10.1016/j.cels.2023.11.003
• 发表时间: 2023
• 期刊: Cell Systems
• 影响因子: 9.3
• 作者: Frank, Steven A.