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Workshop: Systems and Control Theory for Synthetic Biology

研讨会：合成生物学的系统和控制理论

基本信息

批准号：
1941841
负责人：
Domitilla Del Vecchio
金额：
$ 7.82万
依托单位：
Massachusetts Institute of Technology
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1941841&HistoricalAwards=false
关键词：
Workshop Systems Control Theory Synthetic

项目摘要

Synthetic Biology is the engineering of biomolecular processes for useful functionalities for energy, environment, and medical applications. In the past few years, there has been a dramatic increase of the use of systems and control theoretic tools in synthetic biology. Systems and Control Theory has been instrumental in many engineering domains, chiefly in Electrical, Mechanical, and Aerospace engineering for obtaining desirable properties, including stable and robust system behavior in the presence of environmental perturbations. Biomolecular processes suffer from lack of robustness to context and this has been hampering progress in the field. This problem has sparked notable interest in the research community towards using systems and control theoretic tools for equipping engineered biomolecular processes with robust behavior. This award funds a workshop to bring together experts in synthetic biology, in the application of systems and control theory to engineering biology, and in the use of computer science to obtain biological design abstractions. Students from local universities will be invited to the workshop. The workshop, to be held in Spring/Summer 2020, seeks to discuss current challenges in engineering biology and to set a research roadmap for how systems and control theoretic approaches may be used and expanded to tackle some of these challenges. This roadmap will provide researchers a rich set of problems to investigate and will inform decision makers about areas where additional funding may unlock the route of synthetic biology to societal impact. The workshop includes broader talks, technical talks, and several group discussions. Presentations of the outcomes of the group discussions will form the basis for a workshop report, which will be publicly disseminated.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

合成生物学是生物分子过程的工程，用于能源，环境和医疗应用的有用功能。在过去的几年里，合成生物学中系统和控制理论工具的使用急剧增加。系统与控制理论在许多工程领域发挥了重要作用，主要是在电气、机械和航空航天工程中，用于获得所需的特性，包括在存在环境扰动的情况下稳定和鲁棒的系统行为。生物分子过程缺乏对环境的鲁棒性，这一直阻碍着该领域的进展。这个问题引起了研究界对使用系统和控制理论工具装备具有鲁棒行为的工程生物分子过程的显着兴趣。该奖项资助了一个研讨会，汇集了合成生物学，系统和控制理论应用于工程生物学，以及使用计算机科学获得生物设计抽象的专家。当地大学的学生将被邀请参加研讨会。该研讨会将于2020年春季/夏季举行，旨在讨论工程生物学目前面临的挑战，并为如何使用和扩展系统和控制理论方法以应对其中一些挑战制定研究路线图。该路线图将为研究人员提供一系列丰富的问题，并将告知决策者额外资金可能解锁合成生物学社会影响途径的领域。研讨会包括更广泛的会谈，技术会谈和几个小组讨论。小组讨论的成果将成为研讨会报告的基础，该报告将公开分发。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。