Supramolecular approaches for phase organization, particle formation, disintegration, and drug binding capacity in depsipeptide-based nanocarriers (A03)

基于缩肽的纳米载体的相组织、颗粒形成、崩解和药物结合能力的超分子方法 (A03)

• 批准号: 240237147
• 金额: --
• 依托单位: Institut für Membranforschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240237147?language=en
• 关键词: Supramolecular; approaches; phase; organization; particle

The formation of small oligodepsipeptides (ODP)-based nanocarriers with diameters <100 nm is the goal of this project. Drug loading and release will be tailored by employing ODPs strongly stabilizing particles, thereby enabling high drug encapsulation and lowering release rates by forming a dense matrix. Particles of >100 nm will be created, which will be taken up into hair follicles and will then disintegrate on demand upon exposure to an external stimulus into smaller units that are able to permeate from the hair follicle into the surrounding dermis. The capability to disintegrate on demand shall be implemented by a shape-memory effect of the small-sized nanoparticles.

形成直径小于100 nm的基于小寡聚沉积肽（ODP）的纳米载体是本项目的目标。通过采用ODPs强稳定颗粒来定制药物的装载和释放，从而通过形成致密的基质来实现高药物包封和降低释放速度。100纳米的微粒将被吸收到毛囊中，然后在暴露于外部刺激时根据需要分解成更小的单位，能够从毛囊渗透到周围的真皮层。按需分解的能力应通过小尺寸纳米颗粒的形状记忆效应来实现。