Nanocarriers in the skin and oral mucosa of mouse models: Specific targeting of inflammation and role of barrier dysfunctions (C03)

小鼠模型皮肤和口腔粘膜中的纳米载体：炎症的特异性靶向和屏障功能障碍的作用（C03）

• 批准号: 240272098
• 金额: --
• 依托单位: Institut für Tierpathologie (WE12)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240272098?language=en
• 关键词: Nanocarriers; skin; oral; mucosa; mouse

This project focuses on the in vivo testing of nanocarriers for improved anti-inflammatory drug delivery in the skin and oral mucosa of mice. For the second funding period, the JAK-inhibitor tofacitinib will be investigated in the established atopic dermatitis model. Secondly, triggered release mechanisms, based on an altered redox potential, are investigated. Thirdly, the role of additional barrier alterations as seen in UVB irradiated and chronologically aged mouse skin, partially mimicking alterations typical of skin aging, on the penetration and therapeutic potential of established and novel carriers will be studied. Furthermore, oral mucosa will be tested and a mouse tissue bank from all previous and ongoing animal experiments will be established.

该项目的重点是在小鼠皮肤和口腔粘膜中改善抗炎药物递送的纳米载体的体内测试。对于第二个资助期，将在已建立的特应性皮炎模型中研究JAK抑制剂托法替尼。其次，触发释放机制，基于改变的氧化还原电位，进行了研究。第三，将研究在UVB照射和按时间老化的小鼠皮肤中观察到的额外屏障改变的作用，部分模拟皮肤老化的典型改变，对已建立的和新的载体的渗透和治疗潜力。此外，将对口腔粘膜进行检测，并建立所有既往和正在进行的动物实验的小鼠组织库。