CAREER: Scalable Approaches for Multiphysics Fluid Simulation

在过去的十年里，我们看到了个性化血流模拟在医疗实践和生物医学研究中的应用。这些模型被用来帮助设计针对各种疾病的新药、设备和治疗方法。大规模的模拟既捕捉到了流体的运动，也捕捉到了所包含的颗粒和细胞之间的相互作用。这项跨学科的研究将为研究人员创造一种工具，以交互方式修改设备或血管的几何形状或描述细胞的属性，以研究变化如何影响可以改进治疗设计的指标。该项目还将提供一个框架，以促进计算机和生物医学工程交叉的新教育项目，目标是促进人们对STEM学位和职业的更广泛兴趣。为了让下一代科学家参与计算建模，该项目旨在(I)为K-12学生开发基于虚拟现实的互动模块，(Ii)开发符合标准的小学和中学课堂课程附件，以及(Iii)主办实施讲习班，以广泛传播材料和研究结果。拟议的研究计划将开发和建立新的多尺度、多物理建模技术，使用户能够使用并行流体-结构-相互作用(FSI)模型以直观和交互的方式设计新的疗法。该计划结合了包括虚拟现实和增强现实界面、大规模并行流体模拟和高保真细胞黏附模型在内的互补资源。将结合以下关键组成部分：(1)开发一种强大、有效的能力来捕获一系列单元类型；(2)一种并行方法，以初始化复杂几何形状中的高单元密度；以及(3)用于设计反馈和修改的交互技术。由此产生的网络基础设施代表了一种新的、具有潜在变革性的FSI工程范式，它将导致基础知识的进步、更有效的研究技术、增强的临床能力以及超越生物工程和生物医学领域的交叉影响。通过开发最先进的、模拟驱动的、几何交互方法获得的知识将产生广泛的影响，超出了项目中调查的用例。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Over the past decade, we have seen an emergence of the use of personalized blood flow simulations in medical practice and biomedical research. These models are used to help design new drugs, devices, and treatments for a wide range of diseases. Large-scale simulations capture both the fluid movement and the interaction of included particles and cells. This interdisciplinary research will create a tool for researchers to interactively modify the geometry of the device or vessels or properties describing the cells to study how changes influence metrics that can improve treatment design. This project will also provide a framework to facilitate new educational programs at the intersection of computing and biomedical engineering with the goal to promote wider interest in STEM degrees and careers. To engage next generation scientists with computational modeling, the project aims to (i) develop virtual reality-based interactive modules for K-12 students, (ii) develop standards-aligned primary and secondary school classroom curriculum add-ons, and (iii) host implementation workshops to broadly disseminate the material and findings. The proposed research program will develop and establish new multiscale, multiphysics modeling techniques that enable users to use parallel fluid-structure-interaction (FSI) models to design new therapeutics in an intuitive and interactive manner. The program couples complementary resources including virtual reality and augmented reality interfaces, massively parallel fluid simulation, and high-fidelity cellular adhesion models. The following key components will be combined: (i) the development of a robust, efficient capability to capture a range of cell types, (ii) a parallel method to initialize high cell densities in complex geometries, and (iii) interactive techniques for design feedback and modification. The resulting cyberinfrastructure represents a new and potentially transformative FSI engineering paradigm that will lead to advances in fundamental knowledge, more effective research techniques, enhanced clinical capabilities, and cross-cutting impacts that transcend the bioengineering and biomedical fields. The knowledge gained by development of a state-of-the-art, simulation-driven, geometry-interaction methodology will have wide impacts beyond the use cases investigated in the project.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.