The role of X-chromosome inactivation in quantitative trait variation

该项目旨在开发可应用于动物育种、野生动物保护和人类的遗传和基因组研究的方法和软件。X染色体失活(XCI)是一种重要的生物学现象，但其对数量性状变异的影响仍不清楚。该项目旨在开发新的统计方法来估计X连锁遗传变异和逃脱XCI的比例，并识别受XCI影响和不受XCI影响的性状相关遗传变异。然后，这些方法将被应用于来自对大量性状的全基因组关联研究的大型数据集。项目成果可能使我们更好地了解XCI在人类和动物数量性状变异和基因表达中的作用。

This project aims to develop methods and software that can be applied to genetic and genomic studies in animal breeding, wildlife protection, and humans. X-chromosome inactivation (XCI) is an important biological phenomenon but its effect on quantitative trait variation remains largely unknown. This project aims to develop novel statistical methods to estimate the X-linked genetic variance and the proportion that escapes XCI, and identify trait-associated genetic variants affected and not affected by XCI. The methods would then be applied to large datasets from genome-wide association studies for a large number of traits. Project outcomes may enable us to better understand the role of XCI in quantitative trait variation and gene expression in humans and animals.