Deciphering the genetic architecture of human complex traits

破译人类复杂性状的遗传结构

• 批准号: FT180100186
• 负责人: Prof Jian Yang
• 金额: $ 22.38万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-15 至 2020-07-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100186
• 关键词: Deciphering; genetic; architecture; human; complex

This project aims to develop statistical methods to integrate data from genetic studies of complex traits such as stature and cognition. Molecular phenotypes such as gene expression in large samples will be used to predict target genes and regulatory elements of those traits. Understanding the genetic basis of human complex traits is critical to longstanding questions in human and evolutionary biology. The project will also detect signatures of natural selection in shaping the genetic variation in complex traits. The project will provide better understanding of complex traits in global populations and the history of human evolution, and will develop methods applicable in plant and animal contexts.

该项目旨在开发统计方法，以整合身高和认知等复杂性状的遗传研究数据。大样本中的分子表型如基因表达将用于预测这些性状的靶基因和调控元件。了解人类复杂特征的遗传基础对于人类和进化生物学中长期存在的问题至关重要。该项目还将检测自然选择在塑造复杂性状遗传变异方面的特征。该项目将提供对全球人口复杂特征和人类进化史的更好理解，并将开发适用于植物和动物环境的方法。