CAREER: Ruthenium-Catalyzed Stereoselective and Site-selective Functionalization of Carbon-Hydrogen Bond

美国国家科学基金会(NSF)支持密西西比州立大学崔欣教授的研究。该项目由美国国家科学基金会化学部化学催化计划和已建立的激励竞争性研究计划(EPSCoR)共同资助。崔教授正在开发可用于药物和聚合物的有机化合物的新路线。具体的目标是发明一种方法，使有机化合物的行为与它们的镜像不同。这种结构需要依赖于特别精细的化学结构的方法。崔教授建议使用含有Ru元素的催化剂来解决这些挑战。Ru形成具有适当微妙结构的化合物，这有助于形成所需的有机产品。通过对Ru催化剂的系统变化，将获得新的见解。该奖项还支持通过学生对学生的科学教育培养本科生和高中生。为参与课程的本科生提供实验室实践经验。崔教授组织的化学俱乐部为K-12学生提供STEM教育。总体而言，这项研究项目有助于提高化学工业的可持续性和创新力，同时增加美国的技术劳动力。美国国家科学基金会(NSF)支持密西西比州立大学崔欣教授的研究。该项目由美国国家科学基金会化学部化学催化计划和已建立的激励竞争性研究计划(EPSCoR)共同资助。立体选择性的C-H功能化引起了人们的广泛关注，因为它在科学和经济上都有巨大的机遇，但仍然面临着重大的挑战。崔教授正在应对这一挑战，他的研究表明，基于Ru(II)的催化剂对于芳香族C-H键的官能化是非常有效的。更令人感兴趣的是，他的研究揭示了各种有机底物的新的立体选择性，特别是对映选择性的功能化。这些进展为获得新的药物和相关的生物活性化合物打开了大门。目标产品包括生物碱、手性聚合物和未来的手性配体。在一种方法中，正在开发用于授予立体控制的手性导向基团。在另一种方法中，一类新的手性伞形配体实现了对C-H官能化反应的远程立体控制。总体而言，这两个主题提供了新的基本见解，将加强合成方法，并展示Ru(II)催化尚未开发的潜力。在实验室研究的同时，崔教授领导着一个本科生团队，旨在让年轻一代熟悉现代有机化学。他的团队还旨在鼓励高中生和本科生参与。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Professor Cui is developing new routes to organic compounds that could be used in drugs and polymers. The specific goal is the invention of ways to make organic compounds that are behave differently from their mirror images. This type of structure requires methods that rely on particularly subtle chemical structures. Professor Cui proposes to solve these challenges using catalysts containing the element called ruthenium. Ruthenium forms compounds with appropriately subtle structures, which facilitate the formation of desired organic products . New insights will be obtained by systematic changes in the ruthenium catalysts. The award also supports the training of undergraduate and high school students through “student-to-student” science education. Hands-on laboratory experience is provided to participating undergraduates. The chemistry club organized by Professor Cui provide STEM education to K-12 students. Overall, this research project helps to improve the sustainability and innovation of the chemical industry while increasing the technical workforce of the United States.The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Stereoselective C–H functionalization has attracted much attention because the opportunities are significant both scientifically and economically, but still faces major challenges. This challenge is being met by Professor Cui whose research shows that ruthenium(II)-based catalysts are highly effective for functionalization of aromatic C–H bonds. Of still greater interest, his research reveals new stereoselective, particularly enantioselective, functionalization of various organic substrates. These developments open access to new pharmaceuticals and related bioactive compounds. Products targeted include alkaloids, chiral polymers, and future chiral ligands. In one approach, chiral directing groups are being developed for conferring stereocontrol. In another approach, a new class of chiral umbrella-shaped ligands enable long-range stereocontrol of C‒H functionalization reactions. Overall, the two themes are providing new fundamental insights that will enhance synthetic methods as well as to demonstrate the untapped potential of ruthenium(II)-catalysis. In parallel with the laboratory research, Professor Cui leads an undergraduate team that aims to familiarize young generations with modern organic chemistry. His team also aims to encourage the participation of high school and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.