CAREER: Ruthenium-Catalyzed Stereoselective and Site-selective Functionalization of Carbon-Hydrogen Bond

美国国家科学基金会（NSF）支持密西西比州立大学的崔鑫教授的研究。该项目由NSF化学部的化学催化计划和刺激竞争研究的既定计划（EPSCoR）共同资助。 崔教授正在开发可用于药物和聚合物的有机化合物的新途径。 具体目标是发明方法来制造与其镜像不同的有机化合物。这种类型的结构需要依赖于特别微妙的化学结构的方法。 崔教授建议使用含有钌元素的催化剂来解决这些挑战。钌形成具有适当精细结构的化合物，这有助于形成所需的有机产物。通过钌催化剂的系统变化将获得新的见解。该奖项还支持通过“学生对学生”的科学教育培训本科生和高中生。 参与的本科生可亲身体验实验室工作。崔教授组织的化学俱乐部为K-12学生提供STEM教育。 总体而言，这一研究项目有助于提高化学工业的可持续性和创新性，同时增加美国的技术劳动力。美国国家科学基金会（NSF）支持密西西比州立大学的Xin Cui教授的研究。该项目由NSF化学部的化学催化计划和刺激竞争研究的既定计划（EPSCoR）共同资助。 立体选择性C-H功能化反应在科学和经济上都有巨大的发展潜力，但仍面临着巨大的挑战。崔教授正在迎接这一挑战，他的研究表明，钌（II）基催化剂对芳香族C-H键的官能化非常有效。 更令人感兴趣的是，他的研究揭示了各种有机底物的新的立体选择性，特别是对映选择性功能化。这些发展为新的药物和相关的生物活性化合物开辟了道路。目标产物包括生物碱、手性聚合物和未来的手性配体。在一种方法中，正在开发用于赋予立体控制的手性定向基团。在另一种方法中，一类新的手性伞形配体使得能够实现C13 H官能化反应的长程立体控制。总的来说，这两个主题提供了新的基本见解，将加强合成方法，以及展示钌（II）催化的未开发潜力。在实验室研究的同时，崔教授领导了一个本科团队，旨在让年轻一代熟悉现代有机化学。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Professor Cui is developing new routes to organic compounds that could be used in drugs and polymers. The specific goal is the invention of ways to make organic compounds that are behave differently from their mirror images. This type of structure requires methods that rely on particularly subtle chemical structures. Professor Cui proposes to solve these challenges using catalysts containing the element called ruthenium. Ruthenium forms compounds with appropriately subtle structures, which facilitate the formation of desired organic products . New insights will be obtained by systematic changes in the ruthenium catalysts. The award also supports the training of undergraduate and high school students through “student-to-student” science education. Hands-on laboratory experience is provided to participating undergraduates. The chemistry club organized by Professor Cui provide STEM education to K-12 students. Overall, this research project helps to improve the sustainability and innovation of the chemical industry while increasing the technical workforce of the United States.The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Stereoselective C–H functionalization has attracted much attention because the opportunities are significant both scientifically and economically, but still faces major challenges. This challenge is being met by Professor Cui whose research shows that ruthenium(II)-based catalysts are highly effective for functionalization of aromatic C–H bonds. Of still greater interest, his research reveals new stereoselective, particularly enantioselective, functionalization of various organic substrates. These developments open access to new pharmaceuticals and related bioactive compounds. Products targeted include alkaloids, chiral polymers, and future chiral ligands. In one approach, chiral directing groups are being developed for conferring stereocontrol. In another approach, a new class of chiral umbrella-shaped ligands enable long-range stereocontrol of C‒H functionalization reactions. Overall, the two themes are providing new fundamental insights that will enhance synthetic methods as well as to demonstrate the untapped potential of ruthenium(II)-catalysis. In parallel with the laboratory research, Professor Cui leads an undergraduate team that aims to familiarize young generations with modern organic chemistry. His team also aims to encourage the participation of high school and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.