CAREER: New Catalytic Strategies Using Metal-Ligand Charge Transfer

近三分之一的美国国民生产总值是基于化学制造业。这个行业依靠发明新的化学反应来保持竞争力。在这个项目中，加州大学圣地亚哥分校（UCSD）的Valerie Schmidt教授通过设计产生有价值产品的新化学反应，为我们的国家竞争力做出了贡献。新的合成反应有可能用于制造新药、农用化学品和聚合物。该研究的具体主题是开发将碳-碳双键转化为四元环的新方法，称为氧烷和氮杂啶。她的研究小组正在开发使用铜盐作为这些转化的“光催化剂”的方法。考察了铜盐、起始原料和其他试剂对反应产率的影响。施密特教授的研究小组通过在实验室提供动手训练来培养未来的科学家。特别强调的是来自科学背景的学生。该项目还为圣地亚哥县的K-12学生提供科学教育。在化学部化学催化项目的资助下，加州大学圣地亚哥分校的Valerie Schmidt教授正在开发一种新的方法，利用过渡金属催化和光的结合，选择性活化烯烃，合成4元杂环，如氧烷和氮杂环。总体方法代表了对历史悠久但复杂的布吉-帕特诺反应的新视角。总的来说，该研究项目有可能影响药物和其他简单化学构件的合成效率。新化学反应的发展需要对铜(I)预催化剂的配位化学有深入的了解。研究人员正在测试一种机制假设，即金属到配体的电荷转移（MLCT）是[2+2]环加成的关键步骤。该项目旨在通过对底物-催化剂体系的系统修饰来描述一般的催化反应，并使用多种光谱方法分析产物。该项目将广泛影响金属-烯烃配合物的合成用途。施密特教授通过提供无数合成和光谱工具的实践培训来培养未来的科学家。特别强调的是包括来自科学背景不足的学生。该项目还利用流行文化切入点为圣地亚哥县的K-12学生提供科学教育。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Nearly one-third of the United States Gross National Product is based on chemical manufacturing. This industry relies on the invention of new chemical reactions to remain competitive. In this project, Professor Valerie Schmidt of the University of California San Diego (UCSD) contributes to our national competitiveness through the design of new chemical reactions that produce valuable products. The new synthetic reactions have the potential to be used to make new drugs, agrichemicals, and polymers. The specific theme of the research is to develop new ways to convert carbon-carbon double bonds to 4-membered rings called oxetanes and azetidines. Her research group is developing methods that use the copper salts as "photocatalysts" for these conversions. The research investigates the influence of the copper salts, the starting materials, and the other reagents on the efficiency of the reaction to produce products. The research group of Professor Schmidt trains future scientists by providing hands-on training in the laboratory. Particular emphasis is placed on students from backgrounds that are under-represented in science. The project also provides science education to K-12 students in San Diego County.With funding from the Chemical Catalysis Program of the Chemistry Division, Professor Valerie Schmidt of the University of California San Diego is developing new methods for the selective activation of alkenes to synthesize 4-membered heterocycles such as oxetanes and azetidines using a combination of transition metal catalysis and light. The overall methodology represents a new perspective on the time-honored but complicated Buchi-Paterno reaction. Overall, the research program has the potential to impact the efficiency of the synthesis of pharmaceuticals and other simple chemical building blocks. The development of the new chemical reactions requires a thorough understanding of the coordination chemistry of the copper(I) precatalysts. The researchers are testing the mechanistic hypothesis that metal to ligand charge transfer (MLCT) is a key step in the [2+2] cycloaddition. The project aims to describe a general catalytic reaction through methodical modification of the substrate-catalyst system and analyze the products using multiple spectroscopic methods. The project could broadly impact the synthetic utility of metal-alkene complexes. Professor Schmidt trains future scientists by providing hands-on training with a myriad synthetic and spectroscopic tools. Particular emphasis is placed on including students from backgrounds that are under-represented in science. The project also provides science education to K-12 students in San Diego County using pop-culture entry points.This award reflects NSF’s statutory mission and has been deemed worthy of support through evaluation using the Foundation’s intellectual merit and broader impacts review criteria.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.