Keeping it cool: Elucidating the actions of thyronamines in thermoregulation and cardiovascular function

保持凉爽：阐明甲状腺胺在体温调节和心血管功能中的作用

• 批准号: 240382013
• 负责人: Dr. Carolin Stephanie Höfig, Ph.D.
• 金额: --
• 依托单位: Institut für Experimentelle Endokrinologie (CVK)
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240382013?language=en
• 关键词: Keeping; cool; Elucidating; actions; thyronamines

3-Iodothyronamine (3-T1AM) is an endogenous and biologically active cooling substance whose pharmacological actions are opposite to those induced by the classical thermogenic thyroid hormone (TH) T3. Pharmacological doses of 3-T1AM injected into mice lead to profound hypothermia and bradycardia. To date, the mechanisms underlying these effects are still elusive. Given the novel concept that TH can act centrally on thermoregulation and cardiovascular function, we hypothesize that 3-T1AM also affect the central autonomic control of brown fat thermogenesis and heart function. Thus, this project aims to unravel these mechanisms using novel in vivo techniques (e.g. infrared camera, radiotelemetry, blood pressure measurements, stereotaxic injections) to investigate the effect of 3-T1AM and its metabolites in the intact animal. The cellular and tissue localization and characterization of 3-T1AM actions will help to elucidate the underlying molecular mechanisms. In summary, the study will contribute to a better understanding of the counterbalance and physiological homeostasis of thyroid hormone and thyronamine metabolism.

3-碘甲腺原氨酸（3-T1 AM）是一种内源性的具有生物活性的降温物质，其药理作用与经典的产热甲状腺激素（TH）T3所诱导的作用相反。将药理剂量的3-T1 AM注射到小鼠中导致深度体温过低和心动过缓。迄今为止，这些影响的机制仍然是难以捉摸的。鉴于TH可以集中作用于体温调节和心血管功能的新概念，我们假设3-T1 AM也影响棕色脂肪产热和心脏功能的中枢自主控制。因此，本项目旨在使用新的体内技术（例如红外相机，无线电遥测，血压测量，立体定位注射）来研究3-T1 AM及其代谢产物在完整动物中的作用，以揭示这些机制。3-T1 AM作用的细胞和组织定位和表征将有助于阐明潜在的分子机制。总之，这项研究将有助于更好地了解甲状腺激素和甲状腺胺代谢的平衡和生理稳态。