Research hot cell with active air compression and cool down system

申请的主题是一个铅屏蔽、气密的研究热室，带有用于处理短寿命放射性回旋加速器产品的附件。研究热室用于开发约翰内斯古滕贝格大学（JGU）的GE PETtrace 700 S回旋加速器的全部容量，该回旋加速器设计用于生产放射性碳-11（11 C）和氟-18（18 F），但由于缺乏基础设施而无法用于研究。作为JGU放射性药物化学新W3教授任命的一部分，核素11 C和18F成为基于回旋加速器的研究概况的焦点，从基础研究到临床研究。目前，这一目标很难实现，因为用气态11 C工作与无意放射性释放的高风险有关，而放射性合成必须手动进行，即具有低起始放射性。根据操作许可证，11 C和18 F必须交付至01-462室（1264号楼）的热室。这是一个洁净室区域，设计用于生产人类应用的放射性药物。用于制药目的和基础化学研究是不相容的。教学人员几乎无法进入这个房间。放射性核素是用手带进研究实验室的，并在屏蔽通风柜中人工操作，这不是一个及时的标准。没有热室可供研究。对于11 C研究，人工处理是有问题的，因为它与高释放风险相关。该建筑有一个空气过滤系统，防止活动释放到环境中。然而，这种过滤系统不适合低分子量气体，即[11 C]二氧化碳，11 C生产的主要产物，不能被保留。安装一个配备主动空气控制系统的研究热室，以防止在洁净室旁边的实验室中释放受污染的废气，将纠正这种情况。新单元通过目标开关连接到回旋加速器。一个新的客户端工作站允许直接从实验室远程控制回旋加速器。新的细胞解决了上述问题，从而提高了JGU大型DFG资助设备（回旋加速器，PET和PET/MR扫描仪）的有效横截面。未来，细胞中的全自动放射合成将允许使用高11 C和18 F活性，从而可以实现高摩尔活性，以便在理想条件下进行PET研究。热室允许显着增加回旋加速器的研究能力，并为核化学，有机化学，药学，神经科学和核医学工作组之间在放射性药物科学/成像问题上的密切合作提供了广泛的机会。通过将这种研究能力捆绑在一起，新的推动力可以在从基础研究到转化研究的所有领域得到实施。

Subject of the application a lead-shielded, gas-tight research hot cell with accessories for handling short-lived, radioactive cyclotron products. The research hot cell serves to develop the full capacity of the GE PETtrace 700S cyclotron at Johannes Gutenberg University (JGU), which is designed for the production of radioactive carbon-11 (11C) and fluorine-18 (18F) but cannot be used in research due to a lack of infrastructure. As part of the appointment of a new W3 professor for radiopharmaceutical chemistry at JGU, the nuclides 11C and 18F became the focus of a cyclotron-based research profile, from basic research to clinical studies. Currently, this goal is hardly achievable, since working with gaseous 11C is associated with a high risk of unintentional activity release, while radiosynthesis has to be carried out manually, i.e. with low starting activities. As per the operating permit, 11C and 18F must be delivered into a hot cell in room 01-462 (building 1264). This is a clean room area designed for the production of radiopharmaceuticals for human applications. Use for pharmaceutical purposes and basic chemical research are incompatible. The room is practically inaccessible to academic staff. Radionuclides are brought into the research laboratories by hand and manipulated manually in shielded fume hoods, which is not a timely standard. No hot cells are available for research. For 11C research, manual handling is problematic as it is associated with a high risk of release. The building has an air filter system, which prevents the release of activity into the environment. However, this filter system is unsuitable for low-molecular weight gases, i.e. [11C]carbon dioxide, the primary product of 11C production, is not retained. The installation of a research hot cell equipped with an active air containment system to prevent the release of contaminated exhaust air in a lab next to the clean room will remedy the situation. The new cell is connected to the cyclotron via a target switch. A new client station allows for remote control of the cyclotron directly from the laboratory. The new cell solves the above problems and thus improves the effective cross section of the large DFG-funded devices at JGU (cyclotron, PET and PET/MR scanner). In the future, fully automated radiosynthesis in the cell will allow the use of high 11C and 18F activities, so that high molar activities can be achieved in order to carry out PET studies under ideal conditions. The hot cell allows a significant increase in the capacity of the cyclotron in research and opens up a wide range of opportunities for close cooperation between the working groups for nuclear chemistry, organic chemistry, pharmacy, neuroscience and nuclear medicine on issues of radiopharmaceutical sciences/imaging. By bundling such research competence, new impulses can be implemented in everything from basic research to translational research.