Percutaneous laser-assisted resection of the aortic valve

最近，心脏瓣膜支架(带瓣支架)可以通过创新的经导管技术(即经顶端或经股动脉)植入狭窄的主动脉瓣位置。为了避免导管介入过程中的并发症，必须先切除患病的固有瓣膜。为了实现这一目标，在第一个资助期内制定的手术器械和外科技术将在基辅大学医院心血管外科进一步开发和推广。同时，在L大学生物医学光学研究所，用于微创切割心脏瓣膜的激光系统的脉冲能量将进一步增强。这将为钙化和非钙化的心脏瓣膜组织实现尽可能最好的切割效率。所开发的仪器将在活体猪模型和死后人类模型的合作实验中进行优化。此外，激光与组织相互作用的组织学研究将完成拟议的项目。

Recently, heart valve mounted metal scaffolds (valved stents) can be implanted in the position of a stenotic aortic valve via innovative transcatheter technics, i.e. transapically or transfemorally. In order to avoid complications during those catheter interventions, the diseased native valve has to be resected before.To achieve this, the operative instruments as well as the surgical technique elaborated during the first funding period will be further developed and expanded at the Department of Cardiovascular Surgery, University Hospital, Campus Kiel.In parallel, at the Institute for Biomedical Optics of the University Lübeck the pulse energies of the laser system for minimally invasive cutting of heart valves will be further enhanced. This will realize a best possible cutting efficiency for calcified as well as non-calcified heart valve tissue.The developed instrumentation will be optimized in cooperate experiments on an in vivo porcine model and a post mortem human model. Furthermore, histological investigations of laser-tissue interactions will complete the proposed project.