Mechanistic Chemistry of Reactive Sulfur Species

活性硫的机理化学

• 批准号: 1954826
• 负责人: Ming Xian
• 金额: $ 45万
• 依托单位: Washington State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2020-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1954826&HistoricalAwards=false
• 关键词: Mechanistic; Chemistry; Reactive; Sulfur; Species

In this project, funded by the Chemical Structure, Dynamics & Mechanisms B Program of the Chemistry Division, Professor Ming Xian of the Department of Chemistry at Washington State University plans to explore the chemical reactivity and properties of three important reactive sulfur species (hydrogen polysulfides, S-nitroso hydrogen sulfide, and selenopersulfides). These species play regulatory roles in biological systems; However, their mechanisms of action are not clear. Through the studies of their reactivities and reaction mechanisms with other biologically relevant molecules, the investigators seek to determine how these sulfur species regulate biological systems. The research will be carried out by graduate and undergraduate students, as part of their professional training for careers in STEM. Efforts will be made to recruit students from underrepresented groups to participate in this project.Sulfur-based reactive species have been known as critical redox regulators in biological systems. However, the functions of some species such as hydrogen polysulfides, S-nitroso hydrogen sulfide, and selenopersulfides are not well understood. Studies of these molecules are challenging because of their highly reactive nature under physiological conditions. In this project, ways to produce these molecules cleanly will be developed. Studies of their reactivities and reaction mechanisms with other biologically relevant molecules will then become feasible and will be performed. These studies will advance our knowledge of these reactive species and further our understanding of their roles in biological systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由化学系化学结构、动力学机制B计划资助的项目中，华盛顿州立大学化学系的Ming Xian教授计划探索三种重要的活性硫物种（多硫化氢、S-亚硝基硫化氢和硒过硫化物）的化学反应性和性质。这些物种在生物系统中起着调节作用，但其作用机制尚不清楚。 通过研究它们与其他生物相关分子的反应性和反应机制，研究人员试图确定这些硫物种如何调节生物系统。 这项研究将由研究生和本科生进行，作为他们在STEM职业生涯的专业培训的一部分。 将努力招募代表性不足群体的学生参与该项目。硫基反应性物质被认为是生物系统中关键的氧化还原调节剂。然而，一些物种的功能，如多硫化氢，S-亚硝基硫化氢，硒过硫化物还没有得到很好的理解。 对这些分子的研究具有挑战性，因为它们在生理条件下具有高度反应性。 在这个项目中，将开发清洁生产这些分子的方法。 研究它们与其他生物相关分子的反应性和反应机制将变得可行并将进行。 这些研究将推进我们对这些活性物质的了解，并进一步了解它们在生物系统中的作用。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。