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Bio(in)organic Chemistry of Reactive Sulfur and Selenium Species

活性硫和硒的生物（内）有机化学

基本信息

批准号：
2004150
负责人：
Michael Pluth
金额：
$ 43.2万
依托单位：
University of Oregon Eugene
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2026-01-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2004150&HistoricalAwards=false
关键词：
Bio organic Chemistry Reactive Sulfur

项目摘要

With this award, the Chemistry of Life Processes Program in the Chemistry Division is funding Dr. Michael Pluth from the University of Oregon to investigate biologically-relevant reactive sulfur and selenium compounds. These compounds play important roles in biological systems, but in many cases the underlying chemistry and reactivity of these compounds that supports their biological function remains unclear. Dr. Pluth investigates this complex chemistry using relatively simple sulfur-containing model compounds synthesized for this purpose in his laboratory. In addition, the proposed experiments probe differences and similarities between the reactivity of the new sulfur compounds and related, selenium compounds. The research is implemented by graduate and undergraduate students who gain knowledge and skills of bioorganic and bioinorganic chemistry useful in STEM careers in the 21st century. An educational broader impact focuses on the design of hands-on laboratory-based experiments for middle school students and on raising the awareness of the students of the importance of negative experimental results in guiding the design of future areas of scientific investigation.This research project investigates the fundamental chemistry associated with the storage, signaling, and action of reactive sulfur and selenium species relevant to biological system. Specifically, the work probes the chemical mechanisms that differentiate persulfide signaling and hydrogen sulfide release and expands studies on the bioavailability of uninvestigated sulfane sulfur sources. Building on connections to related reactive selenium species, small molecules that allow the modulation of biological hydrogen selenide pools are being developed. Information gained from these investigations is expected to shed light on the connections and interactions among reactive sulfur and selenium species across a range of oxidation states in biological systems. In the longer term, the tools developed in these studies have the potential to help elucidate some of the key roles that the small molecule reduced chalcogenides, H2S (hydrogen sulfide) and H2Se (hydrogen selenide)and their oxidized counterparts play in biological communication and signaling.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有了这个奖项，化学部门的生命过程化学项目资助俄勒冈大学的Michael Pluth博士研究与生物相关的活性硫和硒化合物。这些化合物在生物系统中发挥着重要作用，但在许多情况下，这些化合物支持其生物功能的潜在化学和反应性尚不清楚。普拉斯博士在他的实验室里用相对简单的含硫模型化合物来研究这种复杂的化学反应。此外，所提出的实验还探讨了新硫化合物与相关硒化合物的反应性的异同。该研究由研究生和本科生实施，他们获得了对21世纪STEM职业有用的生物有机和生物无机化学知识和技能。更广泛的教育影响侧重于为中学生设计动手实验，并提高学生对负面实验结果在指导未来科学研究领域设计中的重要性的认识。本研究旨在研究与生物系统相关的活性硫和硒的储存、信号传导和作用相关的基础化学。具体而言，该工作探讨了区分过硫信号和硫化氢释放的化学机制，并扩展了未研究的亚砜硫源的生物利用度研究。基于与相关活性硒物种的联系，可以调节生物硒化氢池的小分子正在开发中。从这些研究中获得的信息有望揭示生物系统中各种氧化态的活性硫和硒之间的联系和相互作用。从长远来看，这些研究中开发的工具有可能帮助阐明小分子还原硫族化合物、硫化氢和硒化氢及其氧化对应物在生物通信和信号传导中发挥的一些关键作用。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。