Selective secretion: a novel mechanism of protein trafficking and its role in Phytophthora pathogenicity

选择性分泌：蛋白质运输的新机制及其在疫霉致病性中的作用

• 批准号: DP0880206
• 负责人: Prof Adrienne Hardham
• 金额: $ 20.82万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0880206
• 关键词: Selective; secretion; novel; mechanism; protein

Agriculturally important crops and over 3,000 Australian native plants are susceptible to diseases caused by Phytophthora, fungus-like pathogens that live in the soil. Economic losses exceed $200m pa and natural ecosystems are being destroyed on a vast scale. Phytophthora control depends upon a limited number of chemical inhibitors to which resistance has already emerged. New control strategies are urgently needed. This research will investigate a novel mechanism for release of infection material recently discovered in Phytophthora cells, and will increase our understanding of how Phytophthora infects host plants, providing vital information required for the development of new, environmentally-safe inhibitors.

农业上重要的作物和超过3000种澳大利亚本土植物很容易受到霉菌引起的疾病，真菌样病原体生活在土壤中。每年的经济损失超过2亿美元，自然生态系统遭到大规模破坏。疫霉菌的控制依赖于数量有限的化学抑制剂，这些抑制剂已经产生了抗性。迫切需要新的控制策略。本研究将探讨最近在疫霉细胞中发现的一种新的释放感染物质的机制，并将增加我们对疫霉如何感染宿主植物的理解，为开发新的、环境安全的抑制剂提供重要信息。