NSF Postdoctoral Fellowship in Biology FY 2020: Developing a maize meristem model to assess the impact of CLAVATA signaling on yield traits

2020 财年 NSF 生物学博士后奖学金:开发玉米分生组织模型以评估 CLAVATA 信号对产量性状的影响

基本信息

  • 批准号:
    2010642
  • 负责人:
  • 金额:
    $ 21.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

This action funds an NSF National Plant Genome Initiative Postdoctoral Research Fellowship in Biology for FY 2020. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Dr. Penelope Lindsay is “Developing a maize meristem model to assess the impact of CLAVATA signaling on yield traits". The host institution for the fellowship is Cold Spring Harbor Laboratory and the sponsoring scientist is Dr. David Jackson.The U.S. is the world’s largest producer of maize, producing 384 million tons annually. With a changing environment and burgeoning global population, we need to maximize maize yield while minimizing agricultural land use. One way to increase maize yield per plant is to increase the amount of seed produced per ear. The maize ear arises from a group of undifferentiated stem cells called the apical meristem. Subtle genetic changes between maize lines affect meristem growth and can have big impacts on yield. This project will build a computational framework to understand how genes function together to regulate the meristem and to form the ear and seeds. Maize lines are very diverse, and this will be used to our advantage to find how differences in these gene networks contribute to making the maize ear. This project will provide the fellow with training in maize genetics and genomics, coupled with bioinformatics and mathematical modeling techniques gleaned through collaborative research. Outreach in plant genetics will occur through High School student and teacher training in plant biology at GenSpace, a community lab space in Brooklyn, NY.This project aims to understand the complex regulation of maize ear development through analysis of the nested association mapping (NAM) founders, a diverse panel of maize lines which vary in both meristem and inflorescence size. Precise phenotypic and transcriptomic analysis of these lines will inform the development of a maize inflorescence meristem model. The model will be used to modulate spatial and quantitative gene expression in silico to generate predictions for effects on maize yield. These predictions can be applied in precision breeding to maximize yield per plant, reducing land use and minimizing agricultural environmental impact. Data generated from this project will be shared in peer-reviewed publications and be presented at national scientific conferences. In addition, transcriptomic data generated from this project will be uploaded to the NCBI Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/). Code generated from modeling the genetic control of the maize inflorescence meristem will be shared on GitHub (https://github.com/).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该行动资助了 2020 财年 NSF 国家植物基因组计划生物学博士后研究奖学金。该奖学金支持该研究员在主办实验室的研究和培训计划,该研究员还提出了一项扩大生物学参与的计划。 Penelope Lindsay 博士的研究和培训计划的标题是“开发玉米分生组织模型以评估 CLAVATA 信号对产量性状的影响”。该奖学金的主办机构是冷泉港实验室,赞助科学家是大卫·杰克逊博士。美国是世界上最大的玉米生产国,每年生产3.84亿吨。随着环境的变化和全球人口的迅速增长,我们需要最大限度地提高玉米产量,同时最大限度地减少农业用地的使用。提高单株玉米产量的一种方法是增加每穗的种子产量。玉米穗由一组称为顶端分生组织的未分化干细胞产生。玉米品系之间微妙的遗传变化会影响分生组织的生长,并对产量产生重大影响。该项目将建立一个计算框架,以了解基因如何共同发挥作用来调节分生组织并形成穗和种子。玉米品系非常多样化,这将有助于我们发现这些基因网络的差异如何有助于形成玉米穗。该项目将为研究员提供玉米遗传学和基因组学方面的培训,以及通过合作研究收集的生物信息学和数学建模技术。植物遗传学的推广将通过纽约布鲁克林社区实验室 GenSpace 的高中生和教师植物生物学培训进行。该项目旨在通过分析嵌套关联图谱 (NAM) 的创建者(分生组织和花序大小各异的多种玉米品系)来了解玉米穗发育的复杂调控。这些品系的精确表型和转录组分析将为玉米花序分生组织模型的开发提供信息。该模型将用于在计算机中调节空间和定量基因表达,以生成对玉米产量影响的预测。这些预测可应用于精准育种,以最大限度地提高单株产量、减少土地使用并最大限度地减少农业环境影响。该项目产生的数据将在同行评审出版物中共享,并在国家科学会议上展示。此外,该项目生成的转录组数据将上传至 NCBI 基因表达综合库 (https://www.ncbi.nlm.nih.gov/geo/)。通过对玉米花序分生组织的遗传控制进行建模而生成的代码将在 GitHub (https://github.com/) 上共享。该奖项反映了 NSF 的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cultivating potential: Harnessing plant stem cells for agricultural crop improvement
  • DOI:
    10.1016/j.molp.2023.12.014
  • 发表时间:
    2024-01-01
  • 期刊:
  • 影响因子:
    27.5
  • 作者:
    Lindsay,Penelope;Swentowsky,Kyle W.;Jackson,David
  • 通讯作者:
    Jackson,David
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Penelope Lindsay其他文献

Penelope Lindsay的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

NSF Postdoctoral Fellowship in Biology: Investigating a Novel Circadian Time-Keeping Mechanism Revealed by Environmental Manipulation
美国国家科学基金会生物学博士后奖学金:研究环境操纵揭示的新型昼夜节律机制
  • 批准号:
    2305609
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Chironomid Bioturbation at Future High Temperature Scenarios and its Effect on Nutrient Fluxes and Bacterial Activity
NSF 生物学博士后奖学金:未来高温场景下的摇蚊生物扰动及其对营养通量和细菌活性的影响
  • 批准号:
    2305738
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Understanding the role of dietary toxins in shaping microbial community dynamics in the gut
NSF 生物学博士后奖学金:了解膳食毒素在塑造肠道微生物群落动态中的作用
  • 批准号:
    2305735
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Was there a Tropical Forest in North America after the end-Cretaceous Extinction?
美国国家科学基金会生物学博士后奖学金:白垩纪末期灭绝后北美是否存在热带森林?
  • 批准号:
    2305812
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Investigating the role of thermal stress response in facilitating adaptation in camel spiders
美国国家科学基金会生物学博士后奖学金:研究热应激反应在促进骆驼蜘蛛适应中的作用
  • 批准号:
    2305969
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Human Domestication of Maize as Bio-cultural Coevolution
美国国家科学基金会生物学博士后奖学金:人类驯化玉米作为生物文化协同进化
  • 批准号:
    2305694
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Potential for Diversified Crop Rotations to Promote Solid Phosphorus Cycling in Agroecosystems
美国国家科学基金会生物学博士后奖学金:多样化作物轮作促进农业生态系统固体磷循环的潜力
  • 批准号:
    2305456
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Priority Effects Within and Between Guilds of Fungal Symbionts
NSF 生物学博士后奖学金:真菌共生体内部和之间的优先效应
  • 批准号:
    2305876
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology: Assessment of interactions between nectarivorous birds and flowering plants to investigate pollination loss in Hawaiian forests
美国国家科学基金会生物学博士后奖学金:评估食蜜鸟类和开花植物之间的相互作用,以调查夏威夷森林的授粉损失
  • 批准号:
    2305728
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
NSF Postdoctoral Fellowship in Biology
NSF 生物学博士后奖学金
  • 批准号:
    2305773
  • 财政年份:
    2024
  • 资助金额:
    $ 21.6万
  • 项目类别:
    Fellowship Award
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了